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A. Infection (~35%)navigator

  1. Abdominal Abscess + Hepatobiliary (~30% of all FUO's)
    1. Cholangitis and Cholecystitis
    2. Hepatic abscess / Subphrenic Abscess
    3. Pancreatic Duct Infection
  2. Endocarditis
  3. Osteomyelitis
  4. AIDs (HIV) and Associated Disease
    1. Cytomegalovirus (CMV), Atypical Mycobacteria, Toxoplasmosis
    2. HIV Associated Lymphoma Lymphoma
    3. HIV Itself
  5. Infectious Mononucleosis (Epstein-Barr Virus Infection)
  6. Tuberculosis
  7. Genitourinary infection (especially in children)
  8. CMV infection
  9. Gastrointestinal Infection
    1. Hepatitic abscesses due to infectious organism
    2. Low grade diarrhea inducing infections (bacterial, protozoal, viral, few fungi)
  10. Asymptomatic sinusitis

B. Malignancy (~35%)navigator

  1. Hodgkin's Disease (usually cyclical pattern, Pel-Epstein Fever)
  2. Non-Hodgkin's Lymphoma
  3. Leukemia (particularly AML-M5 variants)
  4. Renal Cell Carcinoma
  5. Hepatoma or Metastatic Disease to the Liver
  6. Atrial Myxomas

C. Autoimmune / Collagen Vascular Disease (~10%)navigator

  1. SLE
  2. Still's Disease
    1. Usually children with high fever
    2. Evanescent salmon colored rash
    3. Lymphadenopathy and splenomegaly
    4. JRA normal variant
  3. Giant Cell Arteritis
  4. Rheumatic Fever
  5. Inflammatory Bowel Disease
  6. Sarcoidosis

D. Miscellaneousnavigator

  1. Unknown (~10%)
  2. Pulmonary Emboli - recurrent
  3. Acute Thyroiditis
  4. Hematoma - resolving
  5. Granulomatous Hepatitis
  6. Drug Fevers
  7. Whipple's Disease
  8. Hyperimmunoglobulin D Syndrome
  9. Post-Myocardial Infarction Syndrome (with pericarditis)
  10. Kikuchi's Syndrome (necrotizing lymphadenitis)

Resources navigator

calcCelsius ==> Fahrenheit

References navigator

  1. Arnow PM and Flaherty JP. 1997. Lancet. 350:575 abstract