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Ombitasvir, paritaprevir, ritonavir, and dasabuvir is no longer available in the United States.
You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but do not have any symptoms of the disease. In this case, taking the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, stomach pain, or dark urine.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir.
Talk to your doctor about the risk(s) of taking the combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir.
WHY is this medicine prescribed?
The combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir is used alone or in combination with ribavirin (Copegus, Rebetol) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus). Ombitasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Paritaprevir is a protease inhibitor. It works by decreasing the amount of HCV in the body. Ritonavir is a protease inhibitor. It helps to increase the amount of paritaprevir in the body so that the medication will have a greater effect. Dasabuvir is a non-nucleoside NS5B polymerase inhibitor. It works by decreasing the amount of HCV in the body. It is not known if ombitasvir, paritaprevir, ritonavir, or dasabuvir prevent the spread of hepatitis C to other people.
HOW should this medicine be used?
The combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir comes as tablets to take by mouth. This medication comes in a package with 28 days of medication. Each daily dose package has different types of tablets, two containing the combination of ombitasvir, paritaprevir, and ritonavir and two others containing dasabuvir. Take ombitasvir, paritaprevir, and ritonavir (2 tablets) and dasabuvir (1 tablet) every morning with food, then take dasabuvir (1 tablet) every evening with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ombitasvir, paritaprevir, ritonavir, and dasabuvir at around the same time(s) every day. Do not take more or less of it or take it more often than prescribed by your doctor.
The combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir controls HCV but does not cure it. Continue to take ombitasvir, paritaprevir, ritonavir, and dasabuvir even if you feel well. The length of your treatment (12 to 24 weeks) depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking ombitasvir, paritaprevir, ritonavir, and dasabuvir without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before taking ombitasvir, paritaprevir, ritonavir, and dasabuvir,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If you miss a dose of ombitasvir, paritaprevir, and ritonavir, take the missed dose with a meal as soon as you remember it. However, if it is more than 12 hours since the time you should have taken your dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
If you miss a dose of dasabuvir, take the missed dose with a meal as soon as you remember it. However, if it is more than 6 hours since the time you should have taken your dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What SIDE EFFECTS can this medicine cause?
Ombitasvir, paritaprevir, ritonavir, and dasabuvir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
Ombitasvir, paritaprevir, ritonavir, and dasabuvir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the carton it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.
What OTHER INFORMATION should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: August 15, 2020.