Class Name(s):

• 12:12.08.12 Selective beta-2-Adrenergic Agonists

Pronunciation:

• (byoo des' oh nide)
• (al byoo' ter ole)

Brand Name(s):

• Airsupra^®

WHY is this medicine prescribed?

The combination of budesonide and albuterol is used to prevent and treat difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness in adults. Budesonide is in a class of medications called steroids. It works by reducing swelling in the airways. Albuterol is in a class of medications called bronchodilators. It works by relaxing and opening air passages in the lungs, making it easier to breathe.

HOW should this medicine be used?

The combination of budesonide and albuterol comes as an aerosol to inhale by mouth using an inhaler. It is usually taken as 2 puffs as needed to prevent or relieve symptoms. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use budesonide and albuterol exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Do not use more than 12 puffs in 24 hours.

Budesonide and albuterol controls symptoms of asthma but does not cure them. Do not stop using budesonide and albuterol without talking to your doctor.

Before you use the budesonide and albuterol inhaler the first time, read the written instructions that come with it. Ask your doctor, pharmacist, or respiratory therapist to demonstrate the proper technique. Practice using the inhaler while in his or her presence.

Stop using the inhaler and throw the inhaler away when the dose counter shows zero.

To use the inhaler, follow these steps:

1. Remove the protective dust cap from the end of the mouthpiece. Check the mouthpiece for dirt or other objects. Be sure that the canister is fully and firmly inserted in the mouthpiece.
2. If you are using the inhaler for the first time or if you have not used the inhaler in more than 7 days, you will need to prime it. To prime the inhaler, shake it well and then press down on the canister 4 times to release 4 test sprays into the air, away from your face. You will also need to re-prime the inhaler if it has been dropped or if it has been cleaned. To re-prime the inhaler, shake it well and then press down on the canister 2 times to release 2 test sprays into the air, away from your face. Be careful not to get budesonide and albuterol in your eyes. Shake the inhaler prior to each test spray.
3. Shake the inhaler well.
4. Breathe out as completely as possible through your mouth.
5. Hold the canister with the mouthpiece on the bottom, facing you and the canister pointing upward. Place the open end of the mouthpiece into your mouth. Close your lips tightly around the mouthpiece.
6. Breathe in slowly and deeply through the mouthpiece. At the same time, press down once on the container to spray the medication into your mouth.
7. When you have breathed in fully, remove the inhaler from your mouth and close your mouth. Try and hold your breath for about 10 seconds, then breathe out gently.
8. To use 2 puffs, immediately repeat steps 3-7.
9. Replace the protective cap on the inhaler.
10. Rinse your mouth with water and spit the water out. Do not swallow the water.
11. Clean your inhaler once a week. Follow the manufacturer's directions carefully and ask your doctor or pharmacist if you have any questions about cleaning your inhaler.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there OTHER USES for this medication?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before using budesonide and albuterol oral inhalation,

• tell your doctor and pharmacist if you are allergic to budesonide (Pulmicort, Rhinocort, in Symbicort, others), albuterol (Proair, Proventil, Ventolin, others), any other medications, or any of the ingredients in budesonide and albuterol oral inhalation. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you or anyone in your family has or has ever had osteoporosis (a condition in which the bones become thin and weak and break easily) and if you have or have ever had an irregular heartbeat, heart disease, high blood pressure, low levels of potassium in your blood, hyperthyroidism (condition in which there is too much thyroid hormone in the body), diabetes, seizures, tuberculosis (TB; a serious lung infection) in your lungs, cataracts (clouding of the lens of the eye), glaucoma (an eye disease) or high pressure in the eye, or liver disease. Also tell your doctor if you have any type of untreated infection anywhere in your body or a herpes eye infection (a type of infection that causes a sore on the eyelid or eye surface), if you smoke or use tobacco products, or if you are on bedrest or unable to move around.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using budesonide and albuterol oral inhalation, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are using budesonide and albuterol oral inhalation.
• tell your doctor if you have never had chicken pox or measles and you have not been vaccinated against these infections. Stay away from people who are sick, especially people who have chicken pox or measles. If you are exposed to one of these infections or if you develop symptoms of one of these infections, call your doctor right away.
• you should know that budesonide and albuterol inhalation sometimes causes wheezing and difficulty breathing immediately after it is inhaled. If this happens, call your doctor right away. Do not use budesonide and albuterol inhalation again unless your doctor tells you that you should.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Budesonide and albuterol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache
• cough
• white patches in the mouth
• hoarseness

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• increased difficulty breathing
• fast, pounding, or irregular heartbeat
• chest pain
• rash, hives, or itching
• swelling of the face, throat, tongue, lips, hands, feet, ankles, or lower legs
• difficulty swallowing
• fever, chills, and other signs of infection
• tiredness
• nausea
• vomiting
• weakness
• changes in vision

In rare cases, people who used budesonide for a long time developed glaucoma or cataracts. Talk to your doctor about the risks of using budesonide and albuterol and how often you should have your eyes examined during your treatment.

Budesonide and albuterol may increase your risk of developing osteoporosis (a condition in which the bones become thin and weak and break easily). Talk to your doctor about the risks of using this medication.

Budesonide and albuterol may cause growth retardation in children, Budesonide and albuterol should not be used in children.

Budesonide and albuterol may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• seizures
• chest pain
• dizziness
• fast, pounding, or irregular heartbeat
• nervousness
• headache
• shaking of a part of your body that you cannot control
• muscle cramps or weakness
• dry mouth
• nausea
• excessive tiredness
• lack of energy
• difficulty falling asleep or staying asleep

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from sunlight, excess heat and moisture (not in the bathroom). Do not puncture the aerosol canister, and do not discard it in an incinerator or fire.

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: March 15, 2023.