WHY is this medicine prescribed?
Vosoritide is used to increase linear growth (height) in certain children who have achondroplasia (ACH; achondroplastic dwarfism; a genetic condition of bone growth that results in short arms and legs). Vosoritide is in a class of medications called C type natriuretic peptide (CNP) analogs. It works by increasing cartilage cell growth which results in increased bone growth.
HOW should this medicine be used?
Vosoritide comes as a powder to be mixed with liquid to inject subcutaneously (just under the skin). It is usually injected once a day. Inject vosoritide injection at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use vosoritide injection exactly as directed. Do not use more or less of it or take it more often than prescribed by your doctor.
Vosoritide injection may cause a temporary decrease in blood pressure. Your child should eat a meal and drink 8 to 10 ounces of liquid such as water, milk, or juice within 60 minutes before receiving vosoritide injection. Call your doctor or nurse if your child experiences any of the following symptoms that may occur after the injection: dizziness, tiredness, or nausea.
Your healthcare provider will monitor your child's growth carefully during treatment with vosoritide injection and will adjust the dose and the length of treatment based on your child's response to this medication.
If you will be injecting vosoritide injection by yourself at home or having a friend or relative inject the medication for you, your doctor will show you or the person who will be injecting the medication how to mix the medication properly and how to inject it. Before you use vosoritide injection yourself the first time, carefully read the written instructions for use that come with the medication. Ask your doctor or pharmacist if you have any questions about how to mix the medication or do not understand how to inject vosoritide.
Before you are ready to inject vosoritide, you will need to remove the vial of vosoritide and the prefilled diluent syringe from the refrigerator and allow them to warm to room temperature.
You should always look at vosoritide injection solution (liquid) after mixing and before you inject it. The solution should be clear and colorless to yellow, with no particles in it. Do not use vosoritide injection solution if it is colored, cloudy, contains particles, or if the expiration date on the vial has passed.
Use each syringe only once. Dispose of used syringe in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.
Inject vosoritide into the front of the thighs, buttocks, or anywhere on your stomach except your navel (belly button) and the area 2 inches around it. If another person is injecting your medication, the outer area of the upper arms also may be used. Do not inject the medication into skin that is tender, bruised, damaged, or scarred. Choose a different spot each time you inject the medication.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving vosoritide injection,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If it is 12 hours or less after you miss a dose of vosoritide, inject the dose as soon as you remember it. However, if it is more than 12 hours after your missed dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.
What SIDE EFFECTS can this medicine cause?
Vosoritide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Vosoritide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children and away from light. Store vosoritide vials and prefilled diluent syringe in the refrigerator, but do not freeze. Before use, unmixed medication can be stored at room temperature for up to 90 days. Once mixed, use it immediately. It can be stored at room temperature for up to 3 hours after mixing. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: January 15, 2024.