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Cidofovir injection can cause kidney damage. Tell your doctor if you have or have ever had kidney disease. Tell your doctor if you are taking or have recently taken any other medications that may cause kidney damage, some of which include amikacin, amphotericin B (Abelcet, Ambisome), foscarnet (Foscavir), gentamicin, pentamidine (Pentam 300), tobramycin, vancomycin (Vancocin), and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Naprosyn, Aleve). Your doctor will probably tell you not to use cidofovir injection if you are taking or using one or more of these medications.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before, during, after your treatment to check your response to cidofovir injection.
Cidofovir injection has caused birth defects and problems with sperm production in animals. This medication has not been studied in humans, but it is possible that it may also cause birth defects in babies whose mothers received cidofovir injection during pregnancy. You should not use cidofovir injection while you are pregnant or plan to become pregnant unless your doctor decides that this is the best treatment for your condition.
Cidofovir injection has caused tumors in laboratory animals.
Talk to your doctor about the possible risks of using cidofovir injection.
WHY is this medicine prescribed?
Cidofovir injection is used along with another medication (probenecid) to treat cytomegaloviral retinitis (CMV retinitis) in people with acquired immunodeficiency syndrome (AIDS). Cidofovir is in a class of medications called antivirals. It works by slowing the growth of CMV.
HOW should this medicine be used?
Cidofovir injection comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once every 2 weeks. The length of treatment depends on your body's response to the medication.
You must take probenecid tablets by mouth with each dose of cidofovir. Take a dose of probenecid 3 hours before receiving cidofovir injection and again 2 and 8 hours after your infusion is completed. Take probenecid with food to reduce nausea and stomach upset. Ask your doctor or pharmacist if you have any questions about how these medications should be taken together.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before using cidofovir injection,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What SIDE EFFECTS can this medicine cause?
Cidofovir injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
Cidofovir injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your eye doctor. You should have regularly scheduled eye exams during your treatment with cidofovir injection.
Ask your pharmacist any questions you have about cidofovir injection.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
¶ This branded product is no longer on the market. Generic alternatives may be available.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: November 15, 2016.