Class Name(s):

• 10:00 Antineoplastic Agents

Pronunciation:

• (ee flor' ni theen)

Brand Name(s):

• Iwilfin^®

WHY is this medicine prescribed?

Eflornithine is used to treat a certain type of neuroblastoma (a cancer that begins in nerve cells) in adults and children who have completely responded or partially responded to other treatments. Eflornithine is in a class of medications called ornithine decarboxylase (ODC) inhibitors. It works by blocking the action of a substance that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

HOW should this medicine be used?

Eflornithine comes as a tablet to take by mouth. It is usually taken with or without food twice a day. Take eflornithine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take eflornithine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are unable to swallow the tablet(s), you may chew the tablet(s) or you may crush the tablet(s) and mix with 2 tablespoons of soft food or liquid. Eat or drink the mixture right away or within 1 hour of mixing. If any crushed tablet pieces remain, mix with another 2 tablespoons of soft food or liquid, and swallow the entire mixture to make sure you have taken all of the medication.

If you vomit after taking eflornithine, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose of eflornithine, treat you with other medications, or interrupt or stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with eflornithine.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there OTHER USES for this medication?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking eflornithine,

• tell your doctor and pharmacist if you are allergic to eflornithine, any other medications, or any of the ingredients in eflornithine tablets. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have or have ever had hearing problems, a low number of red or white blood cells or platelets, or liver problems.
• tell your doctor if you are pregnant, plan to become pregnant, or plan to father a child. You or your partner should not become pregnant during your treatment with eflornithine. If you are a female that can become pregnant, you will need to have a pregnancy test before you begin treatment, and you should use effective birth control during your treatment and for 1 week after your final dose. If you are a male with a female partner that can become pregnant, use effective birth control during your treatment and for 1 week after your final dose. If you or your partner become pregnant while taking eflornithine, call your doctor. Eflornithine may harm the fetus.
• tell your doctor if you are breast-feeding or plan to breastfeed. Your doctor may tell you not to breast-feed during your treatment and for 1 week after your final dose.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking eflornithine.
• you should know that eflornithine may cause serious hearing problems. Hearing loss may be severe and may require hearing aids. You will need to have a hearing exam before you start taking eflornithine and at least every 6 months during your treatment with eflornithine. Call your doctor right away if you have any of the following symptoms: new or worsening hearing loss or ringing in the ears.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is within 7 hours of the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Eflornithine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• runny nose, sneezing, and congestion
• diarrhea
• vomiting
• burning, red, itchy, crusty, or irritated eyes
• rash
• arm or leg pain
• hair loss
• ear pain or other signs of ear infection

Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:

• fever, chills, cough, sore throat, difficulty urinating, pain when urinating, or other signs of infection
• warm, red, or painful skin; or sores on the skin
• unusual bruising or bleeding
• blood in urine or stool
• pale skin
• unusual tiredness or weakness
• shortness of breath
• yellowing of the skin or eyes, dark-colored (tea-colored) urine, light-colored stools, pain in upper right part of the stomach, nausea, vomiting, or loss of appetite

Eflornithine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to eflornithine.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: February 15, 2024.