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If you have an epidural or spinal anesthesia or a shot in your spine while using a 'blood thinner' such as fondaparinux injection, you could get a blood clot near your spine that can cause paralysis. Tell your doctor if you have or have ever had spinal surgery, problems with medication given through the spine, a spinal deformity, or if you have bleeding problems. Tell your doctor and pharmacist if you are taking other anticoagulants ('blood thinners') such as warfarin, anagrelide, aspirin or nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen), cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, and tirofiban. If you experience any of the following symptoms, call your doctor immediately: muscle weakness, numbness or tingling (especially in your legs), or not being able to move your legs.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to fondaparinux injection.
Talk to your doctor about the risk of using fondaparinux injection.
WHY is this medicine prescribed?
Fondaparinux injection is used to:
Fondaparinux injection is in a class of medications called factor Xa inhibitors. It works by slowing down and stopping blood from clotting.
HOW should this medicine be used?
Fondaparinux injection comes as a solution (liquid) to be injected subcutaneously (under the skin). It is given one time a day. Use fondaparinux injection at around the same time every day.
Use fondaparinux injection exactly as directed. Do not inject more or less of it or inject it more often than prescribed by your doctor.
If you will continue to use fondaparinux after your hospital stay, you or a caregiver can inject fondaparinux. Ask your doctor or pharmacist to show you or the caregiver how to inject it. Before you use fondaparinux injection yourself the first time, read the Patient Information that comes with it. This information includes directions for how to use and inject fondaparinux prefilled safety syringes. Be sure to ask your pharmacist or doctor if you have any questions about how to inject this medication.
Each syringe has enough medication in it for one shot. Do not use the syringe and needle more than one time. Your doctor, pharmacist, or healthcare provider will tell you how to dispose of used needles and syringes safely.
Do not mix fondaparinux injection with other medications or solutions.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before using fondaparinux injection,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
Give the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use more than one dose of fondaparinux injection at the same time.
What SIDE EFFECTS can this medicine cause?
Fondaparinux injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
Fondaparinux injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
What should I know about STORAGE and DISPOSAL of this medication?
Your healthcare provider will tell you how to store your medication. Store your medication only as directed and out of reach of children. Make sure you understand how to store your medication properly. Do not freeze fondaparinux injection.
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.
What OTHER INFORMATION should I know?
Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving fondaparinux injection.
Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: October 15, 2025.