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Linvoseltamab-gcpt injection may cause a serious or life-threatening reaction called cytokine release syndrome (CRS). Your doctor may tell you to take certain medications before receiving linvoseltamab-gcpt injection to help prevent this reaction. If you experience any of the following symptoms during and after your infusion, tell your doctor immediately: fever, chills, fast or irregular heartbeat, muscle pain, shaking, diarrhea, tiredness, weakness, difficulty breathing, shortness of breath, fast heartbeat, or dizziness or lightheadedness.
Linvoseltamab-gcpt injection may also cause serious, life-threatening central nervous system reactions. If you experience any of the following symptoms, tell your doctor immediately: headache; agitation, trouble staying awake, confusion or disorientation, seeing or hearing things that are not real (hallucinations); trouble speaking, writing, thinking, remembering things, paying attention, or understanding things; problems walking, muscle weakness, shaking (tremors), loss of balance, or muscle spasms; numbness and tingling (feeling like "pins and needles"); burning, throbbing, or stabbing pain; changes in your handwriting; and seizures.
You may experience CRS or central nervous system reactions while you receive a dose of linvoseltamab-gcpt but these reactions may occur afterwards. These reactions are more common with the first 2 doses of linvoseltamab-gcpt but may occur at any time during treatment. A doctor or nurse will monitor you carefully during your infusion and you will be hospitalized to monitor your condition for at least 24 hours after your first 2 infusions. Your healthcare provider will give you a Patient Wallet Card with a list of symptoms. If any of these symptoms occur, you should get medical help right away. Carry the card with you at all times during your treatment with linvoseltamab-gcpt injection, and show it to all of your healthcare providers.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to linvoseltamab-gcpt.
You will be given the Medication Guide when you begin treatment with linvoseltamab-gcpt. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm to obtain the Medication Guide.
Talk to your doctor about the risk(s) of receiving linvoseltamab-gcpt.
WHY is this medicine prescribed?
Linvoseltamab-gcpt is used for the treatment of multiple myeloma (a type of cancer of the bone marrow). Linvoseltamab-gcpt is in a class of medications called bispecific T-cell receptor engager antibodies. It works by stimulating the immune system to kill cancer cells.
HOW should this medicine be used?
Linvoseltamab-gcpt comes as a solution (liquid) to be given intravenously (into a vein) by a medical professional in a hospital or medical facility. Your doctor will tell you how often you will receive linvoseltamab-gcpt. The schedule depends on your condition and on how your body responds to the medication. The length of treatment depends on how you respond to the medication.
Your doctor may delay or stop your treatment with linvoseltamab-gcpt injection, or treat you with additional medications, depending on your response to the medication and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving linvoseltamab-gcpt,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If you miss an appointment to receive linvoseltamab-gcpt injection, call your doctor right away.
What SIDE EFFECTS can this medicine cause?
Linvoseltamab-gcpt may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
Linvoseltamab-gcpt may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What OTHER INFORMATION should I know?
Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving linvoseltamab-gcpt.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: August 15, 2025.