Class Name(s):

• 10:00 Antineoplastic Agents

Pronunciation:

• (dur val' ue mab)

Brand Name(s):

• Imfinzi^®

WHY is this medicine prescribed?

Durvalumab injection is used to treat certain types of cancers of the lung, biliary tract (the organs and ducts that make and store bile, the liquid made by the liver), liver, endometrium (the lining of the uterus), and bladder. Durvalumab injection is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.

HOW should this medicine be used?

Durvalumab injection comes as a liquid to be injected into a vein over 60 minutes by a doctor or nurse in a hospital or medical facility. It is usually injected once every 2 to 4 weeks. Your doctor will tell you how often you will receive durvalumab injection. The schedule depends on the condition you have and on how your body responds to the medication.

You will be watched closely during and shortly after your durvalumab infusion to be sure you are not having a serious reaction. Tell your doctor or nurse immediately if you experience any of the following: chills, itching, rash, flushing, difficulty breathing, wheezing, dizziness, fever, feeling faint, back or neck pain, or swelling of your face.

Your doctor may pause or stop your treatment, or treat you with additional medications depending on your response to the medication and side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

Your doctor or pharmacist will give you the Medication Guide. Read the information carefully and ask your doctor or pharmacist if you have any questions.

Are there OTHER USES for this medication?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before receiving durvalumab injection,

• tell your doctor or pharmacist if you are allergic to this drug, any part of this drug, or any other drugs, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have ever had an organ or bone marrow transplant and if you have or have ever had radiation therapy to your chest area. Also tell your doctor if you have or have ever had an autoimmune disease (condition in which the immune system attacks a healthy part of the body) such as Crohn's disease (condition in which the immune system attacks the lining of the digestive tract causing pain, diarrhea, weight loss, and fever), ulcerative colitis (condition that causes swelling and sores in the lining of the colon [large intestine] and rectum), or lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys); any condition that affects your nervous system such as myasthenia gravis (a disorder of the nervous system that causes muscle weakness) or Guillain-Barre syndrome (weakness, tingling, and possible paralysis due to sudden nerve damage); any type of lung disease or breathing problems; diabetes; thyroid problems; or kidney or liver disease. Also tell your doctor if you have or have ever had cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems).
• tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are receiving durvalumab injection. You may need to have a pregnancy test before you start treatment. You should use effective birth control to prevent pregnancy during your treatment and for at least 3 months after your last dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while receiving durvalumab injection, call your doctor immediately. Durvalumab injection may harm the fetus.
• tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while receiving durvalumab injection and for 3 months after your final dose.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

If you miss an appointment to receive durvalumab injection, call your doctor as soon as possible.

What SIDE EFFECTS can this medicine cause?

Durvalumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• swelling of your arms or legs
• constipation
• hair loss
• trouble falling asleep or staying asleep
• muscle or bone pain

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

• new or worsening cough, chest pain, or shortness of breath
• yellowing of your eyes or skin, decreased appetite, dark (tea colored) urine, pain in the upper right part of the stomach, extreme tiredness, or nausea or vomiting
• unusual bleeding or bruising
• diarrhea; stomach pain; or black, tarry, sticky, or bloody stools
• decreased urination, blood in urine, swelling in your ankles, or loss of appetite
• fever, cough, chills, flu like symptoms, frequent or painful urination, or other signs of infection
• headaches that won't go away or unusual headaches; extreme tiredness; weight loss or gain; increased hunger or thirst; feeling dizzy or faint; feeling cold; deepening of voice; constipation; hair loss; changes in mood or behavior such as decreased sex drive, feeling irritable, confused, or forgetful; increased urination; or increased sweating
• fast or irregular heartbeat
• numbness or tingling in the arms or legs
• persistent muscle pain, muscle weakness, muscle cramps, joint pain, joint stiffness or swelling
• rash or itching; scaling or blistering skin; sores in mouth, nose, throat, or genital area; fever or flu-like symptoms; or swollen glands
• neck stiffness
• problems with balance
• blurry or double vision, sensitivity to light, or other vision problems, eye redness or pain
• ongoing pain that begins in the stomach area but may spread to the back, nausea, vomiting, or loss of appetite

Durvalumab injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order a lab test before you begin your treatment to see whether your cancer can be treated with durvalumab injection. Your doctor will order certain lab tests to check your body's response to durvalumab injection.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: August 15, 2025.