WHY is this medicine prescribed?
Nadofaragene firadenovec-vncg is used to treat a certain type of bladder cancer that was not effectively treated with another medication (Bacillus Calmette-Guerin; BCG therapy). Nadofaragene firadenovec-vncg is in a class of medications called gene therapy. It works by helping your body to produce interferon alfa-2b, a natural substance that fights cancer cells in your bladder.
HOW should this medicine be used?
Nadofaragene firadenovec-vncg comes as a suspension (liquid) to be infused (injected slowly) through a catheter (small flexible plastic tube) into your bladder while you are lying down. Nadofaragene firadenovec-vncg solution is given by a doctor or a health care provider in a medical office, hospital, or clinic. It is usually given once every 3 months.
You should keep the medication in your bladder for 1 hour or as long as possible. During the hour after the medication is infused, you will lie on your stomach, back, and sides for 15 minutes each. If you cannot keep the medication in your bladder for the entire hour, tell your health care provider. At the end of 1 hour you will empty your bladder.
Your urine should be disinfected for 2 days after the medication is administered. Pour about one half cup (120 mL) of undiluted bleach in the toilet before you urinate. After urinating, wait 15 minutes before flushing.
You may have symptoms of an irritable bladder during or shortly after treatment with nadofaragene firadenovec-vncg suspension such as a sudden need to urinate or leaking of urine. Tell your doctor if you have bladder cramping or if any nadofaragene firadenovec-vncg suspension leaks out of the bladder.
Your doctor will watch you carefully to see how well treatment with nadofaragene firadenovec-vncg works for you. If you do not respond fully to treatment after 3 months or if your cancer returns, your doctor will probably recommend treatment with surgery.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving nadofaragene firadenovec-vncg,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If you miss an appointment to receive a dose of nadofaragene firadenovec-vncg, call your doctor right away.
What SIDE EFFECTS can this medicine cause?
Nadofaragene firadenovec-vncg may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
Nadofaragene firadenovec-vncg may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: October 15, 2025.