Class Name(s):

• 8:12.24 Tetracyclines

Pronunciation:

• (dem e kloe sye' kleen)

Brand Name(s):

• Declomycin^®Â¶; also available generically

WHY is this medicine prescribed?

Demeclocycline is used to treat infections caused by bacteria includingpneumonia and other respiratory tract infections;; certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Demeclocycline is also used to treat plague and tularemia (serious infections that may be spread on purpose as part of a bioterror attack). Demeclocycline can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning and anthrax (a very serious infection that may be spread on purpose as part of a bioterror attack), Demeclocycline is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria.

Antibiotics such as demeclocycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

HOW should this medicine be used?

Demeclocycline comes as a tablet to take by mouth. It usually is taken two or four times a day. Drink a full glass of water with each dose. Take demeclocycline on an empty stomach at least 1 hour before or 2 hours after meals. Do not take demeclocycline with food, especially dairy products such as milk, yogurt, cheese, and ice cream. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take demeclocycline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Are there OTHER USES for this medication?

Demeclocycline is also sometimes used to treat syndrome of inappropriate antidiuretic hormone (SIADH; condition in which the body produces too much of a certain natural substance that causes the body to retain water). Talk to your doctor about the risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking demeclocycline,

• tell your doctor and pharmacist if you are allergic to demeclocycline, tetracycline, minocycline, doxycycline, any other medications, or any of the ingredients in demeclocycline tablets. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking demeclocycline. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• be aware that antacids containing magnesium, aluminum, or calcium, calcium supplements, iron products, and laxatives containing magnesium interfere with demeclocycline, making it less effective. Take demeclocycline 2 hours before or6 hours after antacids, calcium supplements, and laxatives containing magnesium. Take demeclocycline 2 hours before or4 hours after iron preparations and vitamin products that contain iron.
• tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), or kidney or liver disease.
• you should know that demeclocycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking demeclocycline, call your doctor immediately. Demeclocycline can harm the fetus.
• plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Demeclocycline may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
• you should know that when demeclocycline is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained. Demeclocycline should not be used in children under age 8 unless your doctor decides it is needed.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Demeclocycline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea
• nausea
• vomiting
• changes in skin or mouth color
• throat irritation
• excessive thirst
• frequent urination
• weakness
• inflammation of the end of the penis

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• headache
• blurred vision, seeing double, or loss of vision
• dizziness
• ringing in the ears
• rash
• hives
• peeling or blistering skin
• swelling of the face, throat, tongue, lips, and eyes
• difficulty breathing or swallowing
• unusual bleeding or bruising
• confusion
• swelling of your legs, ankles, or feet
• decreased urination
• joint pain
• chest pain
• watery or bloody stools, stomach cramps, or fever during treatment or for up to two or more months after stopping treatment
• a return of fever, sore throat, chills, or other signs of infection

Demeclocycline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to demeclocycline.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking demeclocycline.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the demeclocycline, call your doctor.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

^¶ This branded product is no longer on the market. Generic alternatives may be available.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: August 15, 2017.