Class Name(s):

• 10:00 Antineoplastic Agents

Pronunciation:

• (lon'' kas tux' i mab tes' ir een)

Brand Name(s):

• Zynlonta^®

WHY is this medicine prescribed?

Loncastuximab tesirine-lpyl injection is used to treat a certain type of non-Hodgkin's lymphoma (NHL; a type of cancer that begins in a type of white blood cells that normally fights infection) that did not respond to or has returned after treatment with at least two other cancer treatments. Loncastuximab tesirine-lpyl is in a class of medications called antibody-drug conjugates. It works by killing cancer cells.

HOW should this medicine be used?

Loncastuximab tesirine-lpyl comes as a powder to be mixed with liquid and injected into a vein over 30 minutes by a doctor or nurse in a hospital or medical facility. It is usually injected once every 3 weeks for as long as your doctor recommends that you receive treatment.

Your doctor will probably treat you with another medication before and for 2 days after each dose to help prevent certain side effects. Your doctor may need to temporarily or permanently stop your treatment or decrease your dose of loncastuximab tesirine-lpyl during your treatment. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with loncastuximab tesirine-lpyl.

You should know that loncastuximab tesirine-lpyl should be administered only into a vein. However, it may leak into surrounding tissue causing severe irritation or damage. Your doctor or nurse will monitor the area near where the medication was injected. If you experience any of the following symptoms, tell your doctor immediately: pain, itching, redness, swelling, or sores near the place where the medication was injected.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there OTHER USES for this medication?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before receiving loncastuximab tesirine-lpyl injection,

• tell your doctor and pharmacist if you are allergic to loncastuximab tesirine-lpyl, any other medications, or any of the ingredients in loncastuximab tesirine-lpyl injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you have or recently have had an infection or if you have or have ever had liver problems.
• tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are receiving loncastuximab tesirine-lpyl. If you are female, you may need to have a pregnancy test before you start treatment, and you should use birth control to prevent pregnancy during your treatment with loncastuximab tesirine-lpyl and for 9 months after your final dose. If you are male, you and your female partner should use birth control during your treatment and continue to use birth control for 6 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you or your partner become pregnant while taking loncastuximab tesirine-lpyl, call your doctor immediately. Loncastuximab tesirine-lpyl may harm the fetus.
• tell your doctor if you are breastfeeding. You should not breastfeed while you are receiving loncastuximab tesirine-lpyl and for 3 months after your final dose.
• you should know that this medication may decrease fertility in men. Talk to your doctor about the risks of receiving loncastuximab tesirine-lpyl injection.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving loncastuximab tesirine-lpyl injection.
• plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Loncastuximab tesirine-lpyl may make your skin sensitive to sunlight.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Loncastuximab tesirine-lpyl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• unusual tiredness or weakness
• nausea
• diarrhea
• stomach pain
• constipation
• decreased appetite
• muscle or joint pain
• darkening of skin

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• rash
• itching
• blistering or peeling skin
• swelling of the hands, feet, ankles, or lower leg
• weight gain
• swelling of the stomach area
• shortness of breath
• difficulty breathing
• chest pain
• fever, chills, headache, sore throat, ongoing cough and congestion, or other signs of infection
• warm, red, painful or swollen skin following a cut or scrape
• unusual bleeding or bruising

Loncastuximab tesirine-lpyl may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to loncastuximab tesirine-lpyl injection.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™ Copyright, 2025. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: June 15, 2021.