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Zanidatamab-hrli injection can cause severe, life-threatening diarrhea. Tell your doctor immediately if you experience any new or worsening diarrhea. Your doctor may tell you to take antidiarrheal medication such as loperamide, and drink plenty of water.
Do not receive zanidatamab-hrli injection if you are pregnant or plan to become pregnant. If you become pregnant while taking zanidatamab, call your doctor immediately. Zanidatamab may harm the fetus. You may be required to have a negative pregnancy test before starting zanidatamab. You should use effective contraception during zanidatamab treatment and for 4 months after. Talk to your doctor about what contraception may be best for you.
You will be given the Medication Guide. Read the information carefully and ask your doctor or pharmacist if you have any questions.
WHY is this medicine prescribed?
Zanidatamab-hrli injection is used to treat certain types of
Zanidatamab-hrli injection is in a class of medications called monoclonal antibodies. It works by stopping the growth of the tumor.
HOW should this medicine be used?
Zanidatamab-hrli injection comes as a powder to be mixed with a liquid and to be given as an intravenous infusion (infusion into the vein) by a doctor or a nurse at a healthcare facility. It is given every 2 or 3 weeks. Your doctor will decide how long you should receive zanidatamab-hrli injection. Your dose may need to be changed, delayed or held based on how you are tolerating the medicine.
Zanidatamab-hrli injection can cause reactions during the infusion. Let your doctor know if you experience any of the following during your zanidatamab-hrli infusion: itching, flushing, rash, fever, chills, muscle or joint pain, fast heartbeat, shortness of breath, cough, chest discomfort, dizziness or lightheadedness, or sudden anxiety. Your doctor will give you additional medicines before each dose of zanidatamab-hrli to help prevent any reactions.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving zanidatamab-hrli,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If you miss a scheduled infusion of zanidatamab-hrli, call your doctor to set up an appointment to receive it right away.
What SIDE EFFECTS can this medicine cause?
Zanadatimab-hrli injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
Zanidatamab-hrli injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to zanidatamab-hrli injection.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: October 15, 2026.