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Idursulfase injection may cause serious or life-threatening allergic reactions. These reactions may occur during and up to 24 hours after your injection. Tell your doctor if you have or have ever had breathing problems or any lung conditions that affect your breathing. If you experience any of the following symptoms, tell your doctor immediately: difficulty breathing, dizziness, rash, hives, or swelling of the throat or tongue.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to Idursulfase injection.
WHY is this medicine prescribed?
Idursulfase injection is used to improve walking ability in people with Hunter Syndrome ((mucopolysaccharidosis type II [MPS II)]; an inherited condition in which the body doesn't break down certain sugar substances in the body called glycosaminoglycans (GAG)). Idursulfase injection is in a class of medications called enzymes. It works by helping to reduce the levels of glycosaminoglycans in the body.
HOW should this medicine be used?
Idursulfase injection comes as a solution (liquid) to be mixed diluted and given intravenously (into a vein) by a healthcare professional. It is given once weekly.
Idursulfase injection controls Hunter's Syndrome but does not cure it. Continue to receive idursulfase injection even if you feel well. Do not stop recieving iursulfase injection without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before taking idursulfase injection,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What SIDE EFFECTS can this medicine cause?
Idursulfase injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
Idursulfase injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to Idursulfase injection.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: May 15, 2026.