Class Name(s):

• 28:32.12 Calcitonin Gene-related Peptide (CGRP) Antagonists

Pronunciation:

• (ep" ti nez' ue mab)

Brand Name(s):

• Vyepti^®

WHY is this medicine prescribed?

Eptinezumab-jjmr injection is used to help prevent migraine headaches (severe, throbbing headaches that may cause nausea and sensitivity to sound or light). Eptinezumab-jjmr injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain natural substance in the body that causes migraine headaches.

HOW should this medicine be used?

Eptinezumab-jjmr injection comes as a solution (liquid) to inject intravenously (into a vein) over 30 minutes at a doctor's office or at home by a nurse. It is given every 3 months.

Your doctor may need to interrupt or stop your infusion if you experience certain side effects. Tell your doctor or nurse immediately if you experience any of the following symptoms during your infusion: itching, rash, flushing, shortness of breath, wheezing, or face swelling.

Are there OTHER USES for this medication?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before receiving eptinezumab-jjmr injection,

• tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while receiving eptinezumab-jjmr injection.
• you should know that your blood pressure may increase during your treatment with eptinezumab-jjmr injection. Your doctor will probably monitor your blood pressure during your treatment.
• tell your doctor if you have or have ever had high blood pressure or circulation problems in your fingers and toes such as Raynaud's disease (fingers and toes feel numb and change skin color to white or blue when exposed to cold temperatures or stress).
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using eptinezumab-jjmr injection, call your doctor.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Eptinezumab-jjmr injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nasal congestion
• sore throat

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• rash; hives; itching; flushing of the face; swelling of your face, mouth, tongue, or throat; difficulty breathing
• numb, cold, painful, or discolored fingers or toes
• severe constipation, constant belly pain, vomiting, or swelling of belly

Eptinezumab-jjmr injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed and out of reach of children. Store it in the refrigerator in the original carton but do not freeze.

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach http://www.upandaway.org

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines websitehttp://goo.gl/c4Rm4pfor more information.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor. Your blood pressure should be checked regularly.

You should keep a headache diary by writing down when you have headaches. Be sure to share this information with your doctor.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: August 15, 2026.