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Iberdomide may cause serious or life-threatening blood clots in your legs, lungs, or other parts of your body. Blood clots can lead to heart attacks, strokes, or death. Tell your doctor if you have or have ever had a blood clot in your lungs or legs; a stroke; high blood pressure; high levels of cholesterol in your blood; a slow, fast, or irregular heartbeat; peripheral vascular disease (narrowing of blood vessels in feet, legs, or arms causing numbness, pain, or coldness in that part of the body); a heart attack; diabetes; or heart disease. Also tell your doctor if you smoke or use tobacco. Your doctor may prescribe other medication to be taken along with iberdomide to decrease this risk. If you experience any of the following symptoms, call your doctor immediately: chest pain; shortness of breath; dizziness or fainting; sudden confusion or trouble speaking or understanding; sudden numbness or weakness of face, arm, or leg on one side of the body; sudden severe headache; sudden severe stomach pain; leg, arm, back, neck, or jaw pain; feeling of warmth in the lower leg; or swelling of the feet, ankles, or lower legs.
Do not take iberdomide if you are pregnant or plan to become pregnant. If you become pregnant while taking iberdomide, call your doctor immediately. Iberdomide may harm the fetus. You may need to have 2 negative pregnancy tests before starting iberdomide. You should use 2 forms of effective birth control to prevent pregnancy or not engage in sexual activity that may lead to pregnancy during your treatment and for 4 weeks after your final dose. Talk to your doctor about the best birth control method for you. If you become pregnant or suspect you have become pregnant while taking iberdomide, stop your treatment and call your doctor immediately.
A program called ZENBEXUS REMS has been set up to make sure that pregnant women do not take iberdomide and that women do not become pregnant while taking iberdomide. All patients can get iberdomide only if they are registered with ZENBEXUS REMS, have a prescription from a doctor who is registered with ZENBEXUS REMS, and fill the prescription at a pharmacy that is registered with ZENBEXUS REMS.
You will be given the Medication Guide. Read the information carefully and ask your doctor or pharmacist if you have any questions.
WHY is this medicine prescribed?
Iberdomide is used to treat certain types of multiple myeloma (a type of cancer of the bone marrow. Iberdomide is in a class of medications called immunomodulatory agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells in the bone marrow.
HOW should this medicine be used?
Iberdomide comes as a capsule to take by mouth. Take with or without food once a day for the first 21 days of a 28 day cycle. Take iberdomide at around the same time every day. Your doctor will determine how many cycles you will receive.
Take iberdomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the capsules whole with water; do not split, chew, or crush them.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before taking iberdomide,
What SPECIAL DIETARY instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
Take the missed dose as soon as you remember it. However, if it has been more than 12 hours since the missed dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What SIDE EFFECTS can this medicine cause?
Iberdomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
Iberdomide may cause secondary malignancies (unrelated cancers) to develop. Talk to your doctor about the risks of taking this medication.
Iberdomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in with desiccant (package placed in bottle to protect from moisture), tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Iberdomide is considered a hazardous drug meaning it could be unsafe for others to come in contact with it. For safe use, do the following:
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: September 15, 2026.