Introduction

Class Name(s):

• 80:12 Vaccines

Brand Name(s):

• Cyfendus^®

Why get vaccinated?

Anthrax Vaccine, Adjuvanted may prevent Anthrax disease that may occur with infection due to Bacillus anthracis.

• skin disease (infection enters through the skin by coming into contact with the bacteria spores) which can appear as itchy, small blisters or bumps on skin that can turn into painless, swollen sores with black center (most commonly seen on neck, face, arms or hand)
• respiratory disease (infection enters through the lungs by inhaling the bacteria spores) that can cause fever and chills, heavy sweats, chest pain or cough or shortness of breath, confusion or dizziness, nausea or vomiting or stomach pain, headaches and/or body aches, extreme tiredness
• gastrointestinal disease (infection enters through the stomach but eating contaminated meat) that can cause fever, chills, swelling of neck or glands, sore throat or hoarseness or painful swallowing, nausea, vomiting (including vomiting blood), diarrhea or bloody diarrhea, headache, red face or eyes, stomach pain or swelling, fainting

Anthrax Vaccine, Adjuvanted does not contain the bacteria. It works by triggering the body to make antibodies against the bacteria to provide a defense against potential infection.

Anthrax Vaccine, Adjuvanted can be given to individuals who have been exposed to the bacteria but have not yet developed the disease to keep them from developing the disease (post-exposure prophylaxis).

How is the vaccine given?

Anthrax Vaccine, Adjuvanted comes as a suspension (liquid) to be given intramuscularly (into the skin) by a healthcare provider.

Anthrax Vaccine, Adjuvanted is given as 2 doses given 2 weeks apart.

What should you tell the person who is giving the vaccine?

Tell your vaccine provider if you:

• have had an allergic reaction to this vaccine, any part of this vaccine, any other vaccine or any drug, food or substance. Tell your vaccine provider about the allergy and what symptoms you had.
• have a weakened immune system due to a condition or medication you are receiving.
• are pregnant or thinking about becoming pregnant. If you discover you are pregnant after receiving the vaccine, call your doctor right away. Anthrax Vaccine, Adjuvanted may cause harm to the fetus. Talk to your vaccine provider about the risks and benefits of receiving this vaccine if you are pregnant.
• are breastfeeding. Effects of Anthrax Vaccine, Adjuvanted on lactation or presence in breast milk is not known.

In some cases, your health care provider may decide to postpone vaccination to a future visit.

What are the risks from vaccination?

Side effects that have been reported with Anthrax Vaccine, Adjuvanted include:

• warmth, tenderness, itching, pain, redness or bruising at the site of injection
• difficulty lifting or moving arm after receiving the injection
• tiredness
• fever
• headache
• muscle aches or pains
• swelling of lymph nodes

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• rash, shortness of breath or difficulty breathing, swelling of face or throat

People sometimes faint after medical procedures, including vaccination. Tell your provider if you feel dizzy or have vision changes or ringing in the ears.

Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your health care provider will usually file this report, or you can do it yourself. Visit http://vaers.hhs.gov or call 1-800-822-7967. VAERS is only for reporting reactions, and VAERS staff members do not give medical advice.

How can I learn more?

• Read the Vaccine Information Sheet (VIS) that your vaccine provider will give you or you can obtain it at http://www.cdc.gov/vaccines/hcp/current-vis/index.html
• Ask your healthcare provider.
• Call your local or state health department.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: June 15, 2026.