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Tividenofusp alfa-eknm injection may cause serious or life-threatening allergic or infusion-related reactions during or soon after the infusion. These reactions may also occur at any time during your treatment. You will be watched closely during and shortly after your infusion to be sure you are not having a serious reaction. Your doctor may give you certain medications before you receive tividenofusp alfa-eknm injection to help to prevent a reaction. If you experience any of the following symptoms, tell your doctor immediately or get emergency medical treatment: difficulty swallowing or breathing; shortness of breath; wheezing; hoarseness; swelling of the face, throat, tongue or lips; hives; flushing; redness of the skin; bumps on the skin; rash; itching; fainting; dizziness; fast heartbeat; tightness of the throat or chest; vomiting; stomach pain; diarrhea; cough; irritablity; headache; fever; chills. Your doctor may need to slow down your infusion or delay or permanently stop your treatment if you experience these side effects.
WHY is this medicine prescribed?
Tividenofusp alfa-eknm Injection is used to treat Hunter syndrome (MPS II; an inherited condition in which certain sugars build up in the body, resulting in brain and organ damage). Tividenofusp alfa-eknm is in a class of medications called enzymes. It works by replacing an enzyme that is normally produced by the body that helps prevent the build up of the sugars in the body.
HOW should this medicine be used?
Tividenofusp alfa-eknm comes as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or a nurse. It is given once a week. Iti s given over at least 4 hours but after time, may be given over 3 hours, if tolerated.
You will receive tividenofusp alfa-eknm injection in a medical facility for at least the first 9 doses. If these doses are tolerated, your doctor may decide that this medication may be given at home under medical supervision.
Your doctor will probably start you on a low dose of tividenofusp alfa-eknm injection and gradually increase your dose, not more than once every 4 weeks.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving tividenofusp alfa-eknm injection,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
If you miss an appointment to receive a dose of tividenofusp alfa-eknm injection, call your doctor right away.
What SIDE EFFECTS can this medicine cause?
Tividenofusp alfa-eknm injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
Tividenofusp alfa-eknm injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to tividenofusp alfa-eknm injection.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: May 15, 2026.