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Sparsentan may cause liver damage. Tell your doctor if you have or have ever had liver disease. Your doctor will order a blood test to be sure your liver is working normally before you start taking sparsentan, every month during the first 12 months of your treatment, and then every 3 months thereafter. Keep all appointments with your doctor and the laboratory. If you experience any of the following symptoms, stop taking sparsentan and call your doctor immediately: extreme tiredness, fatigue, pain in the upper right part of the stomach, nausea, vomiting, loss of appetite, yellowing of the skin or eyes, dark-colored urine, fever, or itching. Your doctor may reduce your dose, or temporarily or permanently stop your treatment with sparsentan if you experience side effects or have abnormal lab results.
Sparsentan must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that sparsentan will cause birth defects (physical problems that are present at birth) or death of the unborn baby. You will need to avoid becoming pregnant during your treatment with sparsentan. You must have a negative pregnancy test before starting sparsentan. You must use effective birth control before starting sparsentan, during treatment, and for 2 weeks after stopping treatment. Talk to your doctor about birth control methods that will work for you. If you think you are pregnant, miss a menstrual period, or have sex without using birth control while taking sparsentan, call your doctor immediately.
Sparsentan is available only through a special restricted distribution program. A FILSPARI REMS program (Risk Evaluation and Mitigation Strategies) has been set up because of the risk of liver damage. You will only be able to receive sparsentan if you, your doctor, and your pharmacy are enrolled in this program.
You will be given the Medication Guide. Read the information carefully and ask your doctor or pharmacist if you have any questions.
Talk to your doctor about the risks of taking sparsentan.
WHY is this medicine prescribed?
Sparsentan is used to reduce proteinuria (increased protein in urine) in certain patients with primary immunoglobulin A (IgA) nephropathy (a kidney disease where IgA deposits build up in the kidneys causing inflammation) and with focal segmental glomerulosclerosis (FSGS; rare kidney disease that causes scarring in sections of the kidney). Sparsentan is in a class of medications called endothelin and angiotensin II receptor antagonists. It works by blocking two substances, endothelin and angiotensin II, that play a role in the progression of kidney disease.
HOW should this medicine be used?
Sparsentan comes as a tablet to take by mouth. Take once a day before your morning meal or before your evening meal. Take sparsentan at around the same time every day and before the same meal.
Take sparsentan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the tablets whole with water.
If you are unable to swallow the tablets whole, you can crush them and mix them in a half cup of water. Drink this mixture right away. Do not use liquids other than water to mix your dose. If there is some of the tablet left in the cup, add more water, swirl, and drink immediately. Do not store the mixture for future use.
Your doctor will probably start you on a low dose of sparsentan and increase your dose after 14 days.
Sparsentan controls proteinuria from IgA nephropathy and FSGS but does not cure them. Continue to take sparsentan even if you feel well. Do not stop taking sparsentan without talking to your doctor.
Sparsentan can cause low blood pressure. It is important to drink plenty of water while receiving sparsentan to keep blood pressure from dropping too low.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before taking sparsentan,
What SPECIAL DIETARY instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication. Also, talk to your doctor before using salt substitutes containing potassium.
What should I do IF I FORGET to take a dose?
If a dose is missed, take the next dose at the normally scheduled time. Do not take double or extra doses.
What SIDE EFFECTS can this medicine cause?
Sparsentan may cause side effects. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:
Sparsentan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Keep sparsentan in its original bottle.
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach. http://www.upandaway.org
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to sparsentan.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: June 15, 2026.