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Semaglutide injection may increase the risk that you will develop thyroid gland tumors, including a type of thyroid cancer. Semaglutide injection caused thyroid tumors in rats. It is not known if this medication increases the risk of tumors in humans. Tell your doctor if you or anyone in your family has or has ever had thyroid tumors, thyroid cancer, or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; condition that causes tumors in more than one gland in the body). If so, your doctor will probably tell you not to use semaglutide injection. If you experience any of the following symptoms, call your doctor immediately: a lump or swelling in the neck; hoarseness; difficulty swallowing; or shortness of breath.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to semaglutide injection.
You will be given the Medication Guide. Read the information carefully and ask your doctor or pharmacist if you have any questions.
Talk to your doctor about the risks of using semaglutide injection.
WHY is this medicine prescribed?
Semaglutide injection is used for the following:
Semaglutide injection is in a class of medications called incretin mimetics. It works to manage diabetes by helping the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Semaglutide injection also slows the emptying of the stomach and may decrease appetite and cause weight loss. Semaglutide injection works in several ways to improve liver function in people with MASH.
HOW should this medicine be used?
Semaglutide injection comes as a solution (liquid) in a prefilled dosing pen to inject subcutaneously (under the skin). It is injected once a week. Use semaglutide injection on the same day each week at any time of day. You may change the day of the week that you use semaglutide as long as it has been 2 or more days since you used your last dose.
Use semaglutide injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of semaglutide injection and increase your dose after 4 weeks. Your doctor may increase your dose again after another 4 weeks based on your body's response to the medication.
Semaglutide injection helps to control diabetes and weight loss, but does not cure it. Continue to use semaglutide injection even if you feel well. Do not stop using semaglutide injection without talking to your doctor.
You will be shown how to use the injection pen by your doctor or nurse. You will also be given instructions for use with the medicine. This will tell you how to inject it. Read it carefully. Ask your pharmacist or doctor if you have any questions about how to inject this medication.
Always look at the semaglutide solution before you inject it. It should be clear, colorless, and free of particles. Do not use semaglutide if it is colored, cloudy, thickened, or contains solid particles, or if the expiration date on the pen has passed.
Never reuse needles and never share needles or pens. Always remove the needle right after you inject your dose. Dispose of needles in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture resistant container.
Inject semaglutide in your upper arm, thigh, or stomach area. Use a different site for each injection.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before using semaglutide injection,
What SPECIAL DIETARY instructions should I follow?
Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian.
What should I do IF I FORGET to take a dose?
if you are taking this medication to control diabetes, inject the missed dose as soon as you remember it within 5 days after the missed dose. However, if more than 5 days have passed, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
if you are taking this medication to for weight loss or maintenance or to treat MASH, inject the missed dose as soon as you remember it within 2 days (48 hours) after the missed dose. However, if you miss a dose and the next scheduled dose is less than 2 days (48 hours) away, skip the dose and resume your regular schedule. Do not take a double dose to make up for a missed one.
What SIDE EFFECTS can this medicine cause?
Semaglutide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNINGS section, call your doctor immediately or get emergency medical treatment:
Semaglutide injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in and out of reach of children. Store it away from light and heat, with the pen cap on.
Store semaglutide pens in the refrigerator (36°F to 46°F [2°C to 8°C]). Do not freeze. Semaglutide pens may also be stored at room temperature for certain amount of time. Talk to your doctor or pharmacist about how long you can store semaglutide pens at room temperature.
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reach http://www.upandaway.org.
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website http://goo.gl/c4Rm4p for more information.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: May 15, 2026.