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Laronidase injection may cause serious or life-threatening allergic reactions. These reactions may occur during and up to 3 hours after your injection. Tell your doctor if you have a respiratory infection or have ever had breathing problems or any lung conditions that affect your breathing. Also tell your doctor if you use supplemental oxygen or a continuous positive airway pressure (CPAP) machine during sleep. If you experience any of the following symptoms, tell your doctor immediately: difficulty breathing, changes in heartbeat, fever, chills, dizziness, rash, hives, or swelling of the throat or tongue.
Talk to your doctor about the risks of receiving laronidase injection.
WHY is this medicine prescribed?
Laronidase injection is used to treat people with Hurler and Hurler-Scheie syndrome (mucopolysaccharidosis type I [MPS I)]; an inherited condition in which the body doesn't break down certain sugar substances in the body called glycosaminoglycans [GAG]). Laronidase injection is in a class of medications called enzymes. It works by helping to reduce the levels of glycosaminoglycans in the body.
HOW should this medicine be used?
Laronidase comes as a solution (liquid) to dilute and give intravenously (into a vein) by a healthcare professional. It is given once weekly at a hospital or healthcare facility.
Your doctor may prescribe medications for you to take prior to your scheduled dose to reduce the risk of serious reactions to laronidase injection. Be sure you take these medicines exactly as prescribed and ask your doctor or pharmacist if you have any questions.
Laronidase controls Hurler and Hurler-Scheie syndromes but does not cure them. Continue to receive laronidase injection even if you feel well. Do not stop receiving laronidase injection without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before receiving laronidase,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What SIDE EFFECTS can this medicine cause?
Laronidase may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience symptoms listed below or in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment.
Laronidase may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to laronidase.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: May 15, 2026.