WHY is this medicine prescribed?
Lebrikizumab-lbkz injection is used to treat eczema (atopic dermatitis; a skin disease that causes dry, itchy skin and red, scaly rashes). Lebrikizumab-lbkz is in a class of medications called interleukin-13 receptor inhibitors. It works by blocking the activity of interleukin-13, a substance in the body that causes inflammation.
HOW should this medicine be used?
Lebrikizumab-lbkz injection comes as a solution (liquid) in prefilled syringes and prefilled pens to be injected subcutaneously (under the skin). It is given once every 2 weeks to start, and then every 4 or 8 weeks as a maintenance dose. Your doctor will tell you how much to use and how often to use lebrikizumab-lbkz injection.
Use lebrikizumab-lbkz injection exactly as directed. Do not inject more or less of it or inject it more often than prescribed by your doctor.
You may receive your first dose of lebrikizumab-lbkz injection in your doctor's office. After that, you may be able to inject the medication yourself at home or have a caregiver perform the injections. Your doctor will show you or the person who will be injecting the medication how to inject it. Read the written instructions for use that come with lebrikizumab-lbkz injection before you inject the medication.
Use each syringe and pen only once and inject all the solution in the syringe or pen. Do not reuse lebrikizumab-lbkz pre-filled syringes. Do not recap the syringes after use. Dispose of used syringes and pens in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.
Always look at lebrikizumab-lbkz injection solution before injecting it. Check that the expiration date has not passed and that the liquid is clear and colorless or pale yellow or brown. Do not use a syringe or pen if it is expired or if the liquid is cloudy, discolored or contains large or colored particles.
You can inject lebrikizumab-lbkz injection on the front of your thighs (upper leg) or stomach area except your navel (belly button) and the area 2 inches (5 centimeters) around it. If someone else is giving you the injection, the back of the upper arm may also be used. Use a different injection site for each injection. Do not inject the medication into damaged, bruised, scarred or tender skin.
Do not shake a syringe or pen that contains lebrikizumab-lbkz injection.
Are there OTHER USES for this medication?
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What SPECIAL PRECAUTIONS should I follow?
Before using lebrikizumab-lbkz injection,
What SPECIAL DIETARY instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do IF I FORGET to take a dose?
Use the missed dose as soon as you remember it and then continue your regular dosing schedule. Do not use a double dose to make up for a missed one. Call your doctor if you are unclear about your dosing schedule.
What SIDE EFFECTS can this medicine cause?
Lebrikizumab-lbkz may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
Lebrikizumab-lbkz injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at http://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the original container it came in, tightly closed, and out of reach of children. Store lebrikizumab-lbkz injection in the refrigerator or at room temperature for up to 7 days. Do not freeze. Keep the syringes and pens in their original cartons to protect them from light.
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location - one that is up and away and out of their sight and reachhttp://www.upandaway.org
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines websitehttp://goo.gl/c4Rm4p for more information
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™ Copyright, 2026. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: August 15, 2026.