Immunologically Mediated Drug Reactions
| Type of Reaction | Representative Examples | Mechanism |
|---|
| Anaphylactic (type 1) | Anaphylaxis
Urticaria
Angioedema | IgE-mediated degranulation of mast cells with resultant mediator release | | Cytotoxic (type 2) | Autoimmune hemolytic anemia
Interstitial nephritis | IgG or IgM antibodies against cell antigens and complement activation | | Immune complex (type 3) | Serum sickness
Vasculitis | Immune complex deposition and subsequent complement activation | | Cell mediated (type 4) | Contact dermatitis
Photosensitivity dermatitis | Activated T cells against cell surface–bound antigens |
|