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Answer

In the EORTC study, combined modality therapy resulted in:

  • Improved locoregional control at 2 years (31% vs. 22%, p = .02)
  • Improved colostomy-free interval (p = .002)
  • No statistically significant difference in overall survival

Reference(s)

  • BartelinkH, RoelofsenF, EschwegeF, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III rand omized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol. 1997;15:2040-2049.