Locoregional failure rates of 10% to 30% have been reported. Higher T and N stage have been associated with higher recurrence rates following CRT.

Recent data suggest that HPV/p16 positivity are prognostic for improved OS in patients with anal carcinoma.

Reference(s)

• DasP, BathiaS, EngC, et al. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Oncol Bio Phys. July1, 2007;68(3): 794-800.
• Serup-HansenE, LinnemannD, Skovrider-RuminskiW, et al. Human papillomavirus genotyping and p16 expression as prognostic factors for patients with American Joint Committee on Cancer stages I to III carcinoma of the anal canal. J Clin Oncol. June10, 2014;32(17): 1812-1817.