HPV type 16 is the subtype most frequently associated with anal cancer. Anal cancer incidence is rising; there were an estimated 5,260 new cases and 720 deaths from anal cancer in the United States in 2010.

Other risk factors include:

• Receptive anal intercourse
• High lifetime number of sexual partners
• Smoking
• Anogenital condylomata
• HIV (via increased HPV infection)

Reference(s)

• American Cancer Society. Cancer Facts and Figures. Atlanta, GA: American Cancer Society; 2010.
• RyanDP, ComptonCC, MayerRJ. Carcinoma of the anal canal. N Engl J Med. 2000;342:792-800.