Potential Causes of Generalized Fatigue
Disease Category | Examples |
---|---|
Infection | HIV, TB, Lyme disease, endocarditis, hepatitis, sinusitis, fungal, EBV, malaria (chronic phase) |
Inflammatory disease | RA, polymyalgia rheumatica, chronic fatigue syndrome, fibromyalgia, sarcoidosis |
Cancer | Lung, GI, breast, prostate, leukemia, lymphoma, metastases |
Psychiatric | Depression, alcoholism, chronic anxiety |
Metabolic | Hypothyroidism, hyperthyroidism, diabetes mellitus, Addison's disease, hyperparathyroidism, hypogonadism, hypopituitarism (TSH, ACTH, growth hormone deficiency), McArdle's disease |
Electrolyte imbalance | Hypercalcemia, hypokalemia, hyponatremia, hypomagnesemia |
Nutrition, vitamin deficiency | Starvation, obesity, iron deficiency, vitamin B12, folic acid deficiency, vitamin C deficiency (scurvy), thiamine deficiency (beriberi) |
Neurologic | Multiple sclerosis, myasthenia gravis, dementia |
Cardiac | Heart failure, CAD, valvular disease, cardiomyopathy |
Pulmonary | COPD, pulmonary hypertension, chronic pulmonary emboli, sarcoidosis |
Sleep disturbances | Sleep apnea, insomnia, restless leg syndrome |
Gastrointestinal | Celiac disease, Crohn's, ulcerative colitis, chronic hepatitis, cirrhosis |
Hematologic | Anemia |
Renal | Renal failure |
Medication | Sedatives, antihistamines, narcotics, β blockers, and many other medications |
Abbreviations: ACTH, adrenocorticotropin hormone; CAD, coronary artery disease; COPD; chronic obstructive pulmonary disorder; EBV, Epstein-Barr virus; RA, rheumatoid arthritis; TSH, thyroid-stimulating hormone.