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Table 62-4

Drugs that Carry Risk of Clinical Hemolysis in Persons with G6PD Deficiency

Definite RiskPossible RiskDoubtful Risk
Antimalarials

Primaquine

Dapsone/chlorproguanila

ChloroquineQuinine
Sulphonamides/sulphones

Sulfamethoxazole

Others

Dapsone

Sulfasalazine

Sulfadimidine

Sulfisoxazole

Sulfadiazine

Antibacterial/antibiotics

Cotrimoxazole

Nalidixic acid

Nitrofurantoin

Niridazole

Ciprofloxacin

Norfloxacin

Chloramphenicol

p-Aminosalicylic acid

Antipyretic/analgesics

Acetanilide

Phenazopyridine

Acetylsalicylic acid high dose (>3 g/d)

Acetylsalicylic acid (<3 g/d)

Acetaminophen

Phenacetin

Other

Naphthalene

Methylene blue

Vitamin K analogues

Ascorbic acid >1 g

Rasburicase

Doxorubicin

Probenecid

aMarketed as Lapdap from 2003 to 2008.