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Table 66-1

Clinical Schema of Lymphoid Neoplasms

Chronic lymphoid leukemias/lymphomas

Chronic lymphocytic leukemia/small lymphocytic lymphoma (99% B cell, 1% T cell)

Prolymphocytic leukemia (90% B cell, 10% T cell)

Large granular lymphocyte leukemia (80% NK cell, 20% T cell)

Hairy cell leukemia (99-100% B cell)

Indolent lymphoma

Follicular center cell lymphoma, grades I and II (100% B cell)

Lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (100% B cell)

Marginal zone lymphoma (100% B cell)

Extranodal (MALT lymphoma)

Nodal (monocytoid B cell lymphoma)

Splenic marginal zone lymphoma

Cutaneous T cell lymphoma (mycosis fungoides) (100% T cell)

Aggressive lymphoma

Diffuse large cell lymphoma (85% B cell, 15% T cell) includes immunoblastic

Follicular center cell lymphoma, grade III (100% B cell)

Mantle cell lymphoma (100% B cell)

Primary mediastinal (thymic) large B cell lymphoma (100% B cell)

Burkitt-like lymphoma (100% B cell)

Peripheral T cell lymphoma (100% T cell)

Angioimmunoblastic lymphoma (100% T cell)

Angiocentric lymphoma (80% T cell, 20% NK cell)

Intestinal T cell lymphoma (100% T cell)

Anaplastic large cell lymphoma (70% T cell, 30% null cell)

Acute lymphoid leukemias/lymphomas

Precursor lymphoblastic leukemia/lymphoma (80% T cell, 20% B cell)

Burkitt's leukemia/lymphoma (100% B cell)

Adult T cell leukemia/lymphoma (100% T cell)

Plasma cell disorders (100% B cell)

Monoclonal gammopathy of uncertain significance

Solitary plasmacytoma

Extramedullary plasmacytoma

Multiple myeloma

Plasma cell leukemia

Hodgkin's lymphoma (cell of origin mainly B cell)

Lymphocyte predominant

Nodular sclerosis

Mixed cellularity

Lymphocyte depleted

Abbreviations: MALT, mucosa-associated lymphatic tissue; NK, natural killer.