Clinical Schema of Lymphoid Neoplasms
Chronic lymphoid leukemias/lymphomas Chronic lymphocytic leukemia/small lymphocytic lymphoma (99% B cell, 1% T cell) Prolymphocytic leukemia (90% B cell, 10% T cell) Large granular lymphocyte leukemia (80% NK cell, 20% T cell) Hairy cell leukemia (99-100% B cell) |
Indolent lymphoma Follicular center cell lymphoma, grades I and II (100% B cell) Lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (100% B cell) Marginal zone lymphoma (100% B cell) Extranodal (MALT lymphoma) Nodal (monocytoid B cell lymphoma) Splenic marginal zone lymphoma Cutaneous T cell lymphoma (mycosis fungoides) (100% T cell) |
Aggressive lymphoma Diffuse large cell lymphoma (85% B cell, 15% T cell) includes immunoblastic Follicular center cell lymphoma, grade III (100% B cell) Mantle cell lymphoma (100% B cell) Primary mediastinal (thymic) large B cell lymphoma (100% B cell) Burkitt-like lymphoma (100% B cell) Peripheral T cell lymphoma (100% T cell) Angioimmunoblastic lymphoma (100% T cell) Angiocentric lymphoma (80% T cell, 20% NK cell) Intestinal T cell lymphoma (100% T cell) Anaplastic large cell lymphoma (70% T cell, 30% null cell) |
Acute lymphoid leukemias/lymphomas Precursor lymphoblastic leukemia/lymphoma (80% T cell, 20% B cell) Burkitt's leukemia/lymphoma (100% B cell) Adult T cell leukemia/lymphoma (100% T cell) |
Plasma cell disorders (100% B cell) Monoclonal gammopathy of uncertain significance Solitary plasmacytoma Extramedullary plasmacytoma Multiple myeloma Plasma cell leukemia |
Hodgkin's lymphoma (cell of origin mainly B cell) Lymphocyte predominant Nodular sclerosis Mixed cellularity Lymphocyte depleted |
Abbreviations: MALT, mucosa-associated lymphatic tissue; NK, natural killer.