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Table 181-6

Selection of Antiepileptic Drugs

Generalized-Onset Tonic-ClonicFocal

Typical

Absence

Atypical Absence, Myoclonic, Atonic
First-Line

Lamotrigine

Valproic acid

Lamotrigine

Carbamazepine

Oxcarbazepine

Phenytoin

Levetiracetam

Valproic acid

Ethosuximide

Lamotrigine

Valproic acid

Lamotrigine

Topiramate

Alternatives

Zonisamidea

Phenytoin

Carbamazepine

Oxcarbazepine

Topiramate

Phenobarbital

Primidone

Felbamate

Topiramate

Zonisamidea

Valproic acid

Tiagabinea

Gabapentina

Lacosamidea

Exogabinea

Phenobarbital

Primidone

Felbamate

Lamotrigine

Clonazepam

Clonazepam

Felbamate

Clobazam

Rufinamide

aAs adjunctive therapy.