Antimicrobial Therapy of Central Nervous System Bacterial Infections Based on Pathogena
Organism | Antibiotic |
---|---|
Neisseria meningitides | |
Penicillin-sensitive | Penicillin G or ampicillin |
Penicillin-resistant | Ceftriaxone or cefotaxime |
Streptococcus pneumonia | |
Penicillin-sensitive | Penicillin G |
Penicillin-intermediate | Ceftriaxone or cefotaxime or cefepime |
Penicillin-resistant | Ceftriaxone (or cefotaxime or cefepime) + vancomycin |
Gram-negative bacilli (except Pseudomonas spp.) | Ceftriaxone or cefotaxime |
Pseudomonas aeruginosa | Ceftazidime or cefepime or meropenem |
Staphylococci spp. | |
Methicillin-sensitive | Nafcillin |
Methicillin-resistant | Vancomycin |
Listeria monocytogenes | Ampicillin + gentamicin |
Haemophilus influenzae | Ceftriaxone or cefotaxime or cefepime |
Streptococcus agalactiae | Penicillin G or ampicillin |
Bacteroides fragilis | Metronidazole |
Fusobacterium spp. | Metronidazole |
aDoses are as indicated in Table 191-2.