Antimicrobial Therapy of Central Nervous System Bacterial Infections Based on Pathogena
| Organism | Antibiotic |
|---|---|
| Neisseria meningitides | |
| Penicillin-sensitive | Penicillin G or ampicillin |
| Penicillin-resistant | Ceftriaxone or cefotaxime |
| Streptococcus pneumonia | |
| Penicillin-sensitive | Penicillin G |
| Penicillin-intermediate | Ceftriaxone or cefotaxime or cefepime |
| Penicillin-resistant | Ceftriaxone (or cefotaxime or cefepime) + vancomycin |
| Gram-negative bacilli (except Pseudomonas spp.) | Ceftriaxone or cefotaxime |
| Pseudomonas aeruginosa | Ceftazidime or cefepime or meropenem |
| Staphylococci spp. | |
| Methicillin-sensitive | Nafcillin |
| Methicillin-resistant | Vancomycin |
| Listeria monocytogenes | Ampicillin + gentamicin |
| Haemophilus influenzae | Ceftriaxone or cefotaxime or cefepime |
| Streptococcus agalactiae | Penicillin G or ampicillin |
| Bacteroides fragilis | Metronidazole |
| Fusobacterium spp. | Metronidazole |
aDoses are as indicated in Table 191-2.