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Table 66-3

International Prognostic Index for NHL

Five clinical risk factors:

Age 60 years

Serum lactate dehydrogenase levels elevated

Performance status 2 (ECOG) or 70 (Karnofsky)

Ann Arbor stage III or IV

>1 site of extranodal involvement

Pts are assigned a number for each risk factor they have.
Pts are grouped differently based on the type of lymphoma.
For diffuse large B-cell lymphoma:
0, 1 factor = low risk:35% of cases; 5-year survival, 73%
2 factors = low-intermediate risk:27% of cases; 5-year survival, 51%
3 factors = high-intermediate risk:22% of cases; 5-year survival, 43%
4, 5 factors = high risk:16% of cases; 5-year survival, 26%
For diffuse large B-cell lymphoma treated with R-CHOP:
0 factor = very good:10% of cases; 5-year survival, 94%
1, 2 factors = good:45% of cases; 5-year survival, 79%
3, 4, 5 factors = poor:45% of cases; 5-year survival, 55%

Abbreviations: ECOG, Eastern Cooperative Oncology Group; NHL, non-Hodgkin's lymphoma; R-CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone.