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Table 121-2

Examples of Commonly Used Nitrates

Usual DoseRecommended Dosing Frequency
Short-acting agents
Sublingual TNG0.3-0.6 mgAs needed
Aerosol TNG0.4 mg (1 inhalation)As needed
Sublingual ISDN2.5-10 mgAs needed
Long-acting agents
ISDN
Oral5-30 mgtid
Sustained-action40 mgbid (once in the A.M., then 7 h later)
TNG ointment (2%)0.5-2qid (with one 7- to 10-h nitrate-free interval)
TNG skin patches0.1-0.6 mg/hApply in morning, remove at bedtime
ISMO
Oral20-40 mgbid (once in the A.M., then 7 h later)
Sustained-action30-240 mgDaily

Abbreviations: TNG, nitroglycerin; ISDN, isosorbide dinitrate; ISMO, isosorbide mononitrate.