Examples of Commonly Used Nitrates
| Usual Dose | Recommended Dosing Frequency | |
|---|---|---|
| Short-acting agents | ||
| Sublingual TNG | 0.3-0.6 mg | As needed |
| Aerosol TNG | 0.4 mg (1 inhalation) | As needed |
| Sublingual ISDN | 2.5-10 mg | As needed |
| Long-acting agents | ||
| ISDN | ||
| Oral | 5-30 mg | tid |
| Sustained-action | 40 mg | bid (once in the A.M., then 7 h later) |
| TNG ointment (2%) | 0.5-2 | qid (with one 7- to 10-h nitrate-free interval) |
| TNG skin patches | 0.1-0.6 mg/h | Apply in morning, remove at bedtime |
| ISMO | ||
| Oral | 20-40 mg | bid (once in the A.M., then 7 h later) |
| Sustained-action | 30-240 mg | Daily |
Abbreviations: TNG, nitroglycerin; ISDN, isosorbide dinitrate; ISMO, isosorbide mononitrate.