The ANN Arbor Staging System for Hodgkin's Lymphoma
| Stage | Definition |
|---|---|
| I | Involvement of a single lymph node region or lymphoid structure (e.g., spleen, thymus, Waldeyer's ring) |
| II | Involvement of two or more lymph node regions on the same side of the diaphragm (the mediastinum is a single site; hilar lymph nodes should be considered “lateralized” and, when involved on both sides, constitute stage II disease) |
| III | Involvement of lymph node regions or lymphoid structures on both sides of the diaphragm |
| III1 | Subdiaphragmatic involvement limited to spleen, splenic hilar nodes, celiac nodes, or portal nodes |
| III2 | Subdiaphragmatic involvement includes paraaortic, iliac, or mesenteric nodes plus structures in III1 |
| IV | Involvement of extranodal site(s) beyond that designated as “E” |
| More than one extranodal deposit at any location | |
| Any involvement of liver or bone marrow | |
| A | No symptoms |
| B | Unexplained weight loss of >10% of the body weight during the 6 months before staging investigation |
| Unexplained, persistent, or recurrent fever with temperatures >38°C (100.5°F) during the previous month | |
| Recurrent drenching night sweats during the previous month | |
| E | Localized, solitary involvement of extralymphatic tissue, excluding liver and bone marrow |