Hereditable (Autosomal Dominant)
Gastrointestinal Polyposis Syndromes | ||||
---|---|---|---|---|
Syndrome | Distribution of Polyps | Histologic Type | Malignant Potential | Associated Lesions |
Familial adenomatous polyposis | Large intestine | Adenoma | Common | None |
Gardner's syndrome | Large and small intestines | Adenoma | Common | Osteomas, fibromas, lipomas, epidermoid cysts, ampullary cancers, congenital hypertrophy of retinal pigment epithelium |
Turcot's syndrome | Large intestine | Adenoma | Common | Brain tumors |
Nonpolyposis syndrome (Lynch syndrome) | Large intestine (often proximal) | Adenoma | Common | Endometrial and ovarian tumors |
Peutz-Jeghers syndrome | Small and large intestines, stomach | Hamartoma | Rare | Mucocutaneous pigmentation; tumors of the ovary, breast, pancreas, endometrium |
Juvenile polyposis | Large and small intestines, stomach | Hamartoma, rarely progressing to adenoma | Rare | Various congenital abnormalities |