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Table 142-3

Causes of Nephrotic Syndrome (NS)

Systemic CausesGlomerular Disease
Diabetes mellitus, SLE, amyloidosis, HIV-associated nephropathy

Membranous

Minimal change disease

Drugs: gold, penicillamine, probenecid, street heroin, NSAIDs, pamidronate, interferonsFocal glomerulosclerosis
Infections: bacterial endocarditis, hepatitis B, shunt infections, syphilis, malaria, hepatic schistosomiasisMembranoproliferative GN
Malignancy: multiple myeloma, light chain deposition disease, Hodgkin's and other lymphomas, leukemia, carcinoma of breast and GI tract

Mesangioproliferative GN

Immunotactoid and fibrillary GN

Abbreviations: GN, glomerulonephritis.

Source: Modified from RJ Glassock, BM Brenner: HPIM-13.