REGIMENS FOR THE TREATMENT OF LATENT TUBERCULOSIS INFECTION (LTBI) IN ADULTSa
| Regimen | Schedule | Duration | Comments |
|---|---|---|---|
| Isoniazid | 300 mg/d (5 mg/kg) | 9 months (6 months acceptable) | Supplement with pyridoxine (25-50 mg daily). |
| Alternative: 900 mg twice weekly (15 mg/kg) | Twice-weekly regimens require directly observed therapy. | ||
| Rifampin | 600 mg/d (10 mg/kg) | 4 months | Broader efficacy studies are needed. |
| Isoniazid plus rifapentineb | 900 mg (15 mg/kg) weekly + 900 mg weekly | 12 weeks | Directly observed therapy is recommended for the once-weekly regimen. |
| This regimen may be supplemented with pyridoxine (25-50 mg/d). |
Source: D Menzies et al: Ann Intern Med 149:689, 2008; American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: Am J Respir Crit Care Med 167:603, 2003; and T Sterling et al: N Engl J Med 365:2155, 2011.
aAdapted from Table 205e-1 in HPIM-19.
bThis regimen is not recommended for HIV-infected pts who are receiving antiretroviral therapy or for pregnant women.