The Physiologic Classification of Anemia

The Physiologic Classification of Anemia - Flowchart

«Flowchart»

Anemia

Hemolysis/hemorrhage

Blood loss
Intravascular hemolysis
Metabolic defect
Membrane abnormality
Hemoglobinopathy
Immune destruction
Fragmentation hemolysis

End

Red cell morphology

Normocytic normochromic

Normocytic

Micro or macrocytic

Micro

Maturation disorder

Nuclear defects

Folate deficiency
Vitamin B₁₂ deficiency
Drug toxicity
Refractory anemia

Nuclear defects

Folate deficiency
Vitamin B₁₂ deficiency
Drug toxicity
Refractory anemia

Folate deficiency
Vitamin B₁₂ deficiency ₁₂
Drug toxicity
Refractory anemia Nuclear defects

Cytoplasmic defects

Iron deficiency
Thalassemia
Sideroblastic anemia

Cytoplasmic defects

Iron deficiency
Thalassemia
Sideroblastic anemia

Iron deficiency
Thalassemia
Sideroblastic anemia Cytoplasmic defects

CBC, reticulocyte count

Index <2.5

Index ≥2.5

≥ Index Greater than equal to 2.5

Hypoproliferative

↓Stimulation

Inflammation
Metabolic defect
Renal disease

↓Stimulation

↓

Inflammation
Metabolic defect
Renal disease

Inflammation
Metabolic defect
Renal disease Stimulation

Iron deficiency

Marrow damage

Infiltration/fibrosis
Aplasia

Marrow damage

Infiltration/fibrosis
Aplasia

Infiltration/fibrosis
Aplasia Marrow