Causes of Isolated Hyperbilirubinemia
- Indirect hyperbilirubinemia
- Hemolytic disorders
- Inherited
- Spherocytosis, elliptocytosis, glucose-6-phosphate dehydrogenase and pyruvate kinase deficiencies
- Sickle cell anemia
- Acquired
- Microangiopathic hemolytic anemias
- Paroxysmal nocturnal hemoglobinuria
- Spur cell anemia
- Immune hemolysis
- Parasitic infections
- Malaria
- Babesiosis
- Ineffective erythropoiesis
- Cobalamin, folate, and severe iron deficiencies
- Thalassemia
- Increased bilirubin production
- Massive blood transfusion
- Resorption of hematoma
- Drugs
- Rifampin
- Probenecid
- Ribavirin
- Inherited conditions
- Crigler-Najjar types I and II
- Gilbert's syndrome
- Direct hyperbilirubinemia
- Inherited conditions
- Dubin-Johnson syndrome
- Rotor syndrome
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