Differential Diagnosis of Parkinsonism
| Parkinson's Disease | Atypical Parkinsonism | Secondary Parkinsonism | Other Neurodegenerative Disorders |
|---|---|---|---|
| Genetic | Multiple-system atrophy (MSA) | Drug-induced | Wilson's disease |
| Sporadic | Cerebellar type (MSA-c) | Tumor | Huntington's disease |
Dementia with Lewy bodies | Parkinson type (MSA-p) Progressive supranuclear palsy Corticobasal ganglionic degeneration Frontotemporal dementia | Infection Vascular Normal-pressure hydrocephalus Trauma Liver failure Toxins (e.g., carbon monoxide, manganese, MPTP, cyanide, hexane, methanol, carbon disulfide) | Neurodegeneration with brain iron accumulation SCA 3 (spinocerebellar ataxia) Fragile X-associated ataxia-tremor-parkinsonism Prion disease Dystonia-parkinsonism (DYT3) Alzheimer's disease with parkinsonism |
Abbreviations: MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.