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Table 42-3

Cholestatic Conditions that May Produce Jaundice

  1. Intrahepatic
    1. Viral hepatitis
      1. Fibrosing cholestatic hepatitis—hepatitis B and C
      2. Hepatitis A, Epstein-Barr virus infection, cytomegalovirus infection
    2. Alcoholic hepatitis
    3. Drug toxicity
      1. Pure cholestasis—anabolic and contraceptive steroids
      2. Cholestatic hepatitis—chlorpromazine, erythromycin estolate
      3. Chronic cholestasis—chlorpromazine and prochlorperazine
    4. Primary biliary cirrhosis
    5. Primary sclerosing cholangitis
    6. Vanishing bile duct syndrome
      1. Chronic rejection of liver transplants
      2. Sarcoidosis
      3. Drugs
    7. Congestive hepatopathy and ischemic hepatitis
    8. Inherited conditions
      1. Progressive familial intrahepatic cholestasis
      2. Benign recurrent cholestasis
    9. Cholestasis of pregnancy
    10. Total parenteral nutrition
    11. Nonhepatobiliary sepsis
    12. Benign postoperative cholestasis
    13. Paraneoplastic syndrome
    14. Veno-occlusive disease
    15. Graft-versus-host disease
    16. Infiltrative disease
      1. TB
      2. Lymphoma
      3. Amyloidosis
    17. Infections
      1. Malaria
      2. Leptospirosis
  2. Extrahepatic
    1. Malignant
      1. Cholangiocarcinoma
      2. Pancreatic cancer
      3. Gallbladder cancer
      4. Ampullary cancer
      5. Malignant involvement of the porta hepatis lymph nodes
    2. Benign
      1. Choledocholithiasis
      2. Postoperative biliary strictures
      3. Primary sclerosing cholangitis
      4. Chronic pancreatitis
      5. AIDS cholangiopathy
      6. Mirizzi's syndrome
      7. Parasitic disease (ascariasis)