AML Classification Systems
World Health Organization Classificationa |
AML with recurrent genetic abnormalities |
AML with t(8;21)(q22;q22); RUNX1-RUNX1T1b |
AML with inv(16)(p13.1;1q22) or t(16;16)(p13.1;q22); CBFB-MYH11b |
Acute promyelocytic leukemia with t(15;17)(q22;q12); PML-RARAb |
AML with t(9;11)(p22;q23); MLLT3-MLL |
AML with t(6;9)(p23;q34); DEK-NUP214 |
AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1 |
AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1 |
Provisional entity: AML with mutated NPM1 |
Provisional entity: AML with mutated CEBPA |
AML with myelodysplasia-related changes |
Therapy-related myeloid neoplasms |
AML not otherwise specified |
AML with minimal differentiation |
AML without maturation |
AML with maturation |
Acute myelomonocytic leukemia |
Acute monoblastic and monocytic leukemia |
Acute erythroid leukemia |
Acute megakaryoblastic leukemia |
Acute basophilic leukemia |
Acute panmyelosis with myelofibrosis |
Myeloid sarcoma |
Myeloid proliferations related to Down syndrome |
Transient abnormal myelopoiesis |
Myeloid leukemia associated with Down syndrome |
Blastic plasmacytoid dendritic cell neoplasm |
Acute leukemia of ambiguous lineage |
Acute undifferentiated leukemia |
Mixed phenotype acute leukemia with t(9;22)(q34;q11,20); BCR-ABL11 |
Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged |
Mixed phenotype acute leukemia, B/myeloid, NOS |
Mixed phenotype acute leukemia, T/myeloid, NOS |
Provisional entity: Natural killer (NK)-cell lymphoblastic leukemia/lymphoma |
French-American-British (FAB) Classificationc |
MO: Minimally differentiated leukemia |
Ml: Myeloblastic leukemia without maturation |
M2: Myeloblastic leukemia with maturation |
M3: Hypergranular promyelocytic leukemia |
M4: Myelomonocytic leukemia |
M4Eo: Variant: Increase in abnormal marrow eosinophils |
M5: Monocytic leukemia |
M6: Erythroleukemia (DiGuglielmo's disease) |
M7: Megakaryoblastic leukemia |
aFrom SH Swerdlow et al (eds): World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, IARC Press, 2008.
bDiagnosis is AML regardless of blast count.
cFrom JM Bennett et al: Ann Intern Med 103:620, 1985.
Abbreviation: AML, acute myeloid leukemia.