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Table 183-3

DRUGS COMMONLY USED FOR TREATMENT OF PARKINSON'S DISEASEa

AgentAvailable DosagesTypical Dosing
Levodopaa
Carbidopa/levodopa10/100, 25/100, 25/250 mg200-1000 mg levodopa/d 2-4 times/d
Benserazide/levodopa25/100, 50/200 mg
Carbidopa/levodopa CR25/100, 50/200 mg
Benserazide/levodopa MDS25/200, 25/250 mg
Parcopa10/100, 25/100, 25/250
Carbidopa/levodopa/entacapone12.5/50/200, 18.75/75/200, 25/100/200, 31.25/125/200, 37.5/150/200, 50/200/200 mg
Dopamine agonists
Pramipexole0.125, 0.25, 0.5, 1.0, 1.5 mg0.25-1.0 mg tid
Pramipexole ER0.375, 0.75, 1.5. 3.0, 4.5 mg1-3 mg/d
Ropinirole0.25, 0.5, 1.0, 3.0 mg6-24 mg/d
Ropinirole XL2, 4, 6, 8 mg6-24 mg/d
Rotigotine patch2-, 4-, 6-, 8-mg patches4-24 mg/d
Apomorphine SC2-8 mg
COMT inhibitors
Entacapone200 mg200 mg with each levodopa dose
Tolcapone100, 200 mg100-200 mg tid
MAO-B inhibitors
Selegiline5 mg5 mg bid
Rasagiline0.5, 1.0 mg1.0 mg QAM

aTreatment should be individualized. Generally, drugs should be started in low doses and titrated to optimal dose.

Note: Drugs should not be withdrawn abruptly but should be gradually lowered or removed as appropriate.

Abbreviations: COMT, catechol-O-methyltransferase; MAO-B, monoamine oxidase type B; QAM, every morning.