The Diagnostic Approach to Hyponatremia - Flowchart
The Diagnostic Approach to Hyponatremia - Flowchart
«Flowchart»

Assessment of volume status

Assessment of volume status

Assessment of volume status

Hypovolemia


Total body water
Total body sodium

Hypovolemia


Total body water
Total body sodium


Total body water
Total body sodium Hypovolemia

Euvolemia (no edema)


Total body water
Total body sodium

Euvolemia (no edema)


Total body water
Total body sodium


Total body water
Total body sodium Euvolemia

Hypervolemia


Total body water
Total body sodium

Hypervolemia


Total body water
Total body sodium


Total body water
Total body sodium Hypervolemia

UNa 20

UNa 20

UNa 20

Na


Renal losses
Diuretic excess
Mineralcorticoid deficiency
Salt-losing deficiency
Bicarbonaturia with renal tubal acidosis and metabolic alkalosis
Ketonuria
Osmotic diuresis
Cerebral salt wasting syndrome


Renal losses
Diuretic excess
Mineralcorticoid deficiency
Salt-losing deficiency
Bicarbonaturia with renal tubal acidosis and metabolic alkalosis
Ketonuria
Osmotic diuresis
Cerebral salt wasting syndrome


Renal losses
Diuretic excess
Mineralcorticoid deficiency
Salt-losing deficiency
Bicarbonaturia with renal tubal acidosis and metabolic alkalosis
Ketonuria
Osmotic diuresis
Cerebral salt wasting syndrome


Renal losses
Diuretic excess
Mineralcorticoid deficiency
Salt-losing deficiency
Bicarbonaturia with renal tubal acidosis and metabolic alkalosis
Ketonuria
Osmotic diuresis
Cerebral salt wasting syndrome


Extrarenal losses
Vomiting
Diarrhea
Third spacing of fluids
Burns
Pancreatitis
Trauma


Extrarenal losses
Vomiting
Diarrhea
Third spacing of fluids
Burns
Pancreatitis
Trauma


Extrarenal losses
Vomiting
Diarrhea
Third spacing of fluids
Burns
Pancreatitis
Trauma


Extrarenal losses
Vomiting
Diarrhea
Third spacing of fluids
Burns
Pancreatitis
Trauma


Glucocorticoid deficiency
Hypothryoidism
Stress
Drugs
Syndrome of inappropriate antidiuretic hormone secretion


Glucocorticoid deficiency
Hypothryoidism
Stress
Drugs
Syndrome of inappropriate antidiuretic hormone secretion


Glucocorticoid deficiency
Hypothryoidism
Stress
Drugs
Syndrome of inappropriate antidiuretic hormone secretion


Glucocorticoid deficiency
Hypothryoidism
Stress
Drugs
Syndrome of inappropriate antidiuretic hormone secretion

Acute or chronic renal failure

Acute or chronic renal failure

Acute or chronic renal failure


Nephrotic syndrome
Cirrhosis
Cardiac failure


Nephrotic syndrome
Cirrhosis
Cardiac failure


Nephrotic syndrome
Cirrhosis
Cardiac failure


Nephrotic syndrome
Cirrhosis
Cardiac failure

End

End

End

UNa 20

UNa 20

Na U(Na) >20

UNa 20

UNa 20

Na U(Na) <20

UNa 20

UNa 20

Na U(Na) >20

UNa 20

UNa 20

Na U(Na) <20