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Table 65-2

Response Criteria in Chronic Myeloid Leukemia

Hematologic
Complete responseaWhite blood cell count <10,000/µL, normalmorphology
Normal hemoglobin and platelet counts
Incomplete responseWhite blood cell count ≥10,000/µl
CytogeneticPercentage of bone marrow metaphases with t(9;22)
Complete response0
Partial response≤35
Minor response36-85b
No response85-100
MolecularPresence of BCR/ABL transcript by RT-PCR
Complete responseNone (<0.1%)
Incomplete responseAny

aComplete hematologic response requires the disappearance of splenomegaly.

bUp to 15% normal metaphases are occasionally seen at diagnosis (when 30 metaphases are analyzed).

Abbreviation: RT-PCR, reverse transcriptase polymerase chain reaction.