Algorithm for Evaluating the Thrombocytopenic Pt - Flowchart
Algorithm for Evaluating the Thrombocytopenic Pt - Flowchart
«Flowchart»

Platelet count <150,000/µL

Platelet count <150,000/µL

Platelet count <150,000/µL

Bone marrow examination

Bone marrow examination

Bone marrow examination

Consider:


Drug-induced thrombocytopenia
Infection-induced thrombocytopenia
Idiopathic immune thrombocytopenia
Congenital thrombocytopenia

Consider:


Drug-induced thrombocytopenia
Infection-induced thrombocytopenia
Idiopathic immune thrombocytopenia
Congenital thrombocytopenia

Consider:


Drug-induced thrombocytopenia
Infection-induced thrombocytopenia
Idiopathic immune thrombocytopenia
Congenital thrombocytopenia


Drug-induced thrombocytopenia
Infection-induced thrombocytopenia
Idiopathic immune thrombocytopenia
Congenital thrombocytopenia

Microangiopathic hemolytic anemias (e.g., DIC, TTP)

Microangiopathic hemolytic anemias (e.g., DIC, TTP)

Microangiopathic hemolytic anemias (e.g., DIC, TTP)

End

End

End

Hemoglobin and white blood count

Hemoglobin and white blood count

Hemoglobin and white blood count

Normal

Normal

Normal

Abnormal

Abnormal

Abnormal

Peripheral blood smear

Peripheral blood smear

Peripheral blood smear

Normal RBC morphology; platelets normal or increased in size

Normal RBC morphology; platelets normal or increased in size

Normal

Fragmented red blood cells

Fragmented red blood cells

Fragmented

Platelets clumped: Redraw in sodium citrate or heparin

Platelets clumped: Redraw in sodium citrate or heparin

Platelets