Risks of Transfusion Complications
| Frequency, Episodes: Unit | |
|---|---|
| Reactions | |
| Febrile (FNHTR) | 1-4:100 |
| Allergic | 1-4:100 |
| Delayed hemolytic | 1:1000 |
| TRALI | 1:5000 |
| Acute hemolytic | 1:12,000 |
| Fatal hemolytic | 1:100,000 |
| Anaphylactic | 1:150,000 |
| Infectionsa | |
| Hepatitis B | 1:220,000 |
| Hepatitis C | 1:1,800,000 |
| HIV-1, HIV-2 | 1:2,300,000 |
| HTLV-I, HTLV-II | 1:2,993,000 |
| Malaria | 1:4,000,000 |
| Other complications | |
| RBC allosensitization | 1:100 |
| HLA allosensitization | 1:10 |
| Graft-versus-host disease | Rare |
aInfectious agents rarely associated with transfusion, theoretically possible, or of unknown risk include West Nile virus, hepatitis A virus, parvovirus B-19, Babesia microti (babesiosis), Borrelia burgdorferi (Lyme disease), Anaplasma phagocytophilum (human granulocytic ehrlichiosis), Trypanosoma cruzi (Chagas' disease), Treponema pallidum, and human herpesvirus 8.
Abbreviations: FNHTR, febrile nonhemolytic transfusion reaction; HLA, human leukocyte antigen; HTLV, human T lymphotropic virus; TRALI, transfusion-related acute lung injury.