Osmoregulation Versus Volume Regulation
| Osmoregulation | Volume Regulation | |
|---|---|---|
| What is sensed | Plasma osmolality | Arterial filling |
| Sensors | Hypothalamic osmoreceptors | Carotid sinus |
| Afferent arteriole | ||
| Atria | ||
| Effectors | AVP | Sympathetic nervous system |
| Thirst | Renin-angiotensin-aldosterone system | |
| ANP/BNP | ||
| AVP | ||
| What is affected | Urine osmolality | Urinary sodium excretion |
| H2O intake | Vascular tone |
Note: See text for details.
Abbreviations: ANP, atrial natriuretic peptide; AVP, arginine vasopressin; BNP, brain natriuretic peptide.
Source: Adapted from Rose BD, Black RM (eds): Manual of Clinical Problems in Nephrology. Boston, Little Brown, 1988; with permission.