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Table 134-1

Major Categories of Alveolar and Interstitial Inflammatory Lung Disease

Lung Response: Alveolitis, Interstitial Inflammation, and Fibrosis
Known cause
AsbestosRadiation
Fumes, gasesAspiration pneumonia
Drugs (antibiotics, amiodarone, gold) and chemotherapy drugsResidual of adult respiratory distress syndrome

Smoking-related

Desquamative interstitial pneumonia

Respiratory bronchiolitis-associated interstitial lung disease

Langerhans cell granulomatosis (eosinophilic granulomatosis of the lung)

Unknown cause
Idiopathic interstitial pneumoniasPulmonary alveolar proteinosis
Idiopathic pulmonary fibrosis (usual interstitial pneumonia)Lymphocytic infiltrative disorders (lymphocytic interstitial pneumonitis associated with connective tissue disease)
Eosinophilic pneumonias
Acute interstitial pneumonia (diffuse alveolar damage)

Lymphangioleiomyomatosis

Amyloidosis

Cryptogenic organizing pneumonia (bronchiolitis obliterans with organizing pneumonia)

Inherited diseases

Tuberous sclerosis, neurofibromatosis, Niemann-Pick disease, Gaucher's disease, Hermansky-Pudlak syndrome

Nonspecific interstitial pneumonia

Connective tissue diseases

Systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, systemic sclerosis, Sjögren's syndrome, polymyositis-dermatomyositis

Gastrointestinal or liver diseases (Crohn's disease, primary biliary cirrhosis, chronic active hepatitis, ulcerative colitis)

Graft-versus-host disease (bone marrow transplantation; solid organ transplantation)

Pulmonary hemorrhage syndromes

Goodpasture's syndrome, idiopathic pulmonary hemosiderosis, isolated pulmonary capillaritis

Lung Response: Granulomatous
Known cause
Hypersensitivity pneumonitis (organic dusts)Inorganic dusts: beryllium, silica
Unknown cause
SarcoidosisBronchocentric granulomatosis
Granulomatous vasculitidesLymphomatoid granulomatosis
Granulomatosis with polyangiitis (Wegener's), allergic granulomatosis of Churg-Strauss