Major Categories of Alveolar and Interstitial Inflammatory Lung Disease
Lung Response: Alveolitis, Interstitial Inflammation, and Fibrosis | |
Known cause | |
Asbestos | Radiation |
Fumes, gases | Aspiration pneumonia |
Drugs (antibiotics, amiodarone, gold) and chemotherapy drugs | Residual of adult respiratory distress syndrome |
Smoking-related Desquamative interstitial pneumonia Respiratory bronchiolitis-associated interstitial lung disease Langerhans cell granulomatosis (eosinophilic granulomatosis of the lung) | |
Unknown cause | |
Idiopathic interstitial pneumonias | Pulmonary alveolar proteinosis |
Idiopathic pulmonary fibrosis (usual interstitial pneumonia) | Lymphocytic infiltrative disorders (lymphocytic interstitial pneumonitis associated with connective tissue disease) |
Eosinophilic pneumonias | |
Acute interstitial pneumonia (diffuse alveolar damage) | Lymphangioleiomyomatosis Amyloidosis |
Cryptogenic organizing pneumonia (bronchiolitis obliterans with organizing pneumonia) | Inherited diseases Tuberous sclerosis, neurofibromatosis, Niemann-Pick disease, Gaucher's disease, Hermansky-Pudlak syndrome |
Nonspecific interstitial pneumonia | |
Connective tissue diseases Systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, systemic sclerosis, Sjögren's syndrome, polymyositis-dermatomyositis | Gastrointestinal or liver diseases (Crohn's disease, primary biliary cirrhosis, chronic active hepatitis, ulcerative colitis) Graft-versus-host disease (bone marrow transplantation; solid organ transplantation) |
Pulmonary hemorrhage syndromes Goodpasture's syndrome, idiopathic pulmonary hemosiderosis, isolated pulmonary capillaritis | |
Lung Response: Granulomatous | |
Known cause | |
Hypersensitivity pneumonitis (organic dusts) | Inorganic dusts: beryllium, silica |
Unknown cause | |
Sarcoidosis | Bronchocentric granulomatosis |
Granulomatous vasculitides | Lymphomatoid granulomatosis |
Granulomatosis with polyangiitis (Wegener's), allergic granulomatosis of Churg-Strauss |