Ceftriaxone (2 g IV q24h) or cefotaxime (2 g IV q6-8 h) or

Moxifloxacin (400 mg IV q24h), ciprofloxacin (400 mg IV q8h), or levofloxacin (750 mg IV q24h) or

Ampicillin/sulbactam (3 g IV q6h) or

Ertapenem (1 g IV q24h)

1. A β-lactam:

   Ceftazidime (2 g IV q8h) or cefepime (2 g IV q8-12h) or

   Piperacillin/tazobactam (4. 5 g IV q6h) or

   Imipenem (500 mg IV q6h or 1 g IV q8h) or meropenem (1 g IV q8h)

   plus

2. A second agent active against gram-negative bacterial pathogens:

   Gentamicin or tobramycin (7 mg/kg IV q24h) or amikacin (20 mg/kg IV q24h) or

   Ciprofloxacin (400 mg IV q8h) or levofloxacin (750 mg IV q24h)

   plus

3. An agent active against gram-positive bacterial pathogens:

   Linezolid (600 mg IV q12h) or

   Vancomycin (15 mg/kg q12h initially with adjusted doses)